module 13 Upper GI tract, PUD, GERD

Question 1

fundus

Answer 1

mucus secreting cells

Question 2

body

Answer 2

parietal cells

chief cells

Question 3

parietal cells

Answer 3

secrete acid, intrinsic factor

• stimulated by Ach, gastrin, and histamine
• regulated through positive and negative feedback

Question 4

chief cells

Answer 4

secrete pepsinogen

Question 5

antrum

Answer 5

cells that secrete gastrin

Question 6

Ach and acid secretion

Answer 6

triggered by CNS response to food

nerve

Question 7

gastrin and acid secretion

Answer 7

triggered by Ach stimulation of G cells in antrum

blood vessel

Question 8

histamine and acid secretion

Answer 8

triggered by stimuli in the parietal cells

ECL cell

Question 9

protection of gastric lining

Answer 9

mucus
prostaglandin
somatostatin
bicarb
blood flow

Question 10

PUD 3 important factors with development

Answer 10

bacteria infection with H. pylori
NSAID use
cigarette smoking

Question 11

Goals of PUD therapy

Answer 11

dec. gastric acidity
enhance mucosal defenses
eliminate H. pylori

Question 12

NSAID induced GI damage direct

Answer 12

inhibit COX

• > dec. prostaglandins
• > inc. gastric acid, dec. bicarb/mucus, dec. blood flow

Question 13

NSAID induced GI damage indirect

Answer 13

inc. neutrophil adherence to vascular endothelial cells

- > mucosal damage due to neutrophil derived free radicals and proteases

Question 14

GERD

Answer 14

esophageal mucosa is damaged by the reflux of low pH material into the lower esophagus

• heartburn
• not caused by H. pylori