module 2 anti-inflammatory asthma agents Flashcards
corticosteroid drugs
beclomethasone triamcinolone ciclesonide fluticasone budesonide flunisolide mometasone
corticosteroid MOA
alter genetic transcription
- inc B2 receptors and anti-inflammatory proteins
- dec. pro-inflammatory proteins
- apoptosis of inflammatory cells
- indirect mast cell inhibition
corticosteroid use
COPD
Asthma
systemic: severe acute attaches, hospitalizations
corticosteroid AE
osteopenia/porosis delayed growth in peds oropharyngeal candidiasis hoarseness hyperglycemia
corticosteroid administration
inhaled:
- 25% reaches airway
systemic/po: high first pass
Corticosteroid labs
blood glucose
Cromolyns drugs
cromolyn
nedocromil
Cromolyns MOA
stabilize mast cells
- inhibit release of inflammatory mediators from
- eosinophils, neutrophils, monocytes, macrophages, lymphocytes
Cromolyns use
prophylactic asthma therapy
- will not provide relief after initiation of attack
leukotriene inhibitor drugs
zileuton
montelukast
zafirlukast
-PO
leukotriene inhibitors MOA
zileuton: prevent leukotriene production
montelukast/zafirlukast: prevent leukotriene binding to airway receptors
zileuton AE
hepatotoxicity
leukotriene inhibitor precautions
hepatically metabolized
anti-IgE antibody drug
omalizumab
omalizumab MOA
humanized mouse monoclonal antibody binds to IgE -> dec. circulating IgE -> prevents IgE and mast cell binding down regulation of receptors.
