module 1 synch

Question 1

pharmacodynamics

Answer 1

what the drug does to the body

Question 2

pharmacokinetics

Answer 2

what the body does to the drug

Question 3

pKa

Answer 3

half of drug concentration ionized, half non-ionized

- basic drug in base will stay together

Question 4

nonionized, lipophilic drugs favored for

Answer 4

oral absorption

Question 5

weak acids best absorbed

Answer 5

in stomach

Question 6

weak bases are best absorbed

Answer 6

in small intestine

Question 7

drugs with low Vd may be

Answer 7

highly protein bound and more likely to remain in plasma

Question 8

induction and substrates (CYP450)

Answer 8

drugs that are substrates are generally more rapid and extensively metabolized
- reduce concentrations -> dec. drug effect of substrate drug

Question 9

inhibition and substrates

Answer 9

will generally increase plasma concentrations of drugs that are substrates
- inc. drug effect and possibly toxicity of substrate drugs

Question 10

CYP450 induction

Answer 10

inc. production of enzyme
dec. degradation
induction by another drug or autoinduction

Question 11

cyp450 inhibition

Answer 11

incidental or deliberate
competitive inhibition
irreversible inhibition

Question 12

full agonist

Answer 12

activates receptor with maximal efficacy

Question 13

partial agonist

Answer 13

activates receptor but not with maximal efficacy

Question 14

inverse agonist

Answer 14

inactivates constitutively active receptor

Question 15

maximum effect

Answer 15

further inc. in drug dose will not cause inc. response -> receptor is said to be saturated

Question 16

Therapeutic index

Answer 16

TI=LD50/ED50
LD50: lethal dose for 50% of population
ED50: effective dose for 50% of population