module 16 wt management 2

Question 1

serotonin agent med

Answer 1

lorcaserin

Question 2

lorcaserin MOA

Answer 2

selectively activates 5HT
stimulates pro-opiomelanocortin (POMC) neurons
activates melanocortin Rc
-> dec. appetite

Question 3

lorcaserin AE

Answer 3

HA
dizzy 
dry mouth
nausea
constipation
RARE
- mood changes
- suicide ideation
- serotonin syndrom 
- neuroleptic malignant syn.

Question 4

lorcaserin admin

Answer 4

liver metabolism: into 2 inactive metabolites

urine excretion

Question 5

lorcaserin CI

Answer 5

severe renal impairment
HF
valve disorders

Question 6

lorcaserin DI

Answer 6

SSRI
SNRI
MAOI

Question 7

lorcaserin monitoring

Answer 7

valve disorders

• auscultate for murmurs
• s/s HF

Question 8

lorcaserin EDU

Answer 8

discontinue if haven’t lost 5% of body weight in 12 weeks

Question 9

combo agents for wt loss

Answer 9

phentermine/topiramate

Question 10

phentermine/topiramate MOA

Answer 10

inc. NE and DA release and inhibits reuptake
- > fight or flight response
- > dec. appetite

Question 11

phentermine/topiramate AE

Answer 11

topiramate: teratogenic
- cleft palate
- LBW
- fetal metabolic acidosis

Question 12

phentermine/toperimate CI

Answer 12

preg: need to be on birth control 
MAOI in 14 days: HTN
Hx CV disease
uncontrolled HTN
hyperthyroidism
glaucoma
drug misuse
CAUTION
- elderly
- HTN
- DM
- renal impairment

Question 13

liraglutide CI

Answer 13

medullary thyroid carcinoma or family Hx

multiple endocrine neoplasia syndrome 2

Question 14

liraglutide AE

Answer 14

thyroid C-cell tumor risk

Question 15

naltrexone/bupropion MOA

Answer 15

naltrexone: opioid antagonist
bupropion: inhibit NE and DA reuptake

Question 16

naltrexone/bupropion AE

Answer 16

BB: 
- suicidality
- behavior change
- hostility
- aggression 
insomnia
vomiting
HA
dizzy
dry mouth

Question 17

naltrexone/bupropion CI

Answer 17

opioid dependence

acute opioid withdrawal

Question 18

naltrexone/bupropion admin

Answer 18

avoid admin with high fat meals

Question 19

naltrexone/bupropion EDU

Answer 19

discontinue if wt loss < 5% after 12wks