module 3 antidepressants and neurotransmitters

Question 1

serotonin (5HT)

Answer 1

neurotransmitter that modulates

• mood
• sleep wake cycle
• motivation
• pain perception

Question 2

norepinephrine

Answer 2

neurotransmitter that modulates

• mood
• sleep wake cycle
• motivation
• pain perception

Question 3

serotonin synthesis

Answer 3

tryptophan–tryptophan hydroxyase -> serotonin

• packaged in vesicles
• action potential -> release of serotonin into synapse
• autoreceptors, reuptake

Question 4

autoreceptors

Answer 4

negative feedback on presynaptic neuron

- tells body to make more or less of neurotransmitter

Question 5

MAO

Answer 5

breaks down serotonin or norepi that has been reuptaken

Question 6

norepi synthesis

Answer 6

tyrosine -> L-DOPA -> dopamine -> Norepi

• packaged in vesicles
• action potential -> release of norepi into synapse
• autoreceptors, reuptake

Question 7

patho of depression

Answer 7

dec. serotonin and/or norepi neurotransmission

- inc. neurotransmitters does not always alleviate depression

Question 8

acute treatment of depression

Answer 8

TCA or SSRI

- inhibit reuptake of neurotransmitter, allowing for more time in the synapse

Question 9

long-term treatment of depression

Answer 9

down regulation of autoreceptors

-> inc. neurotrasmitter in the synapse

Question 10

Serotonin (5HT) effect

Answer 10

increase appetite
improved sleep
improved mood

Question 11

serotonin 5HT1a effect

Answer 11

improved mood

Question 12

serotonin AE

Answer 12

improve over time
5HT2: 
- inc. anxiety
- jitteriness
- sexual dysfunction 
- sleep disurbances
5HT3:
- nausea
- diarrhea

Question 13

norepi effects

Answer 13

inc. interest
inc. energy
inc. concentration
improved mood

Question 14

norepi AE

Answer 14

inc. HR
inc. BP
anxiety

Question 15

serotonin off target effects

Answer 15

H1: sedation, weight gain
M1 anticholinergic: dry mouth, constipation…
A1 antagonism: vasodliation, dec. BP, orthostasis