module 3 anti-alzheimer's drugs

Question 1

alzheimer’s patho

Answer 1

depleted levels of AcH

persistent activation of NMDA receptors by glutamate -> memory loss

Question 2

acetylcholinesterase inhibitors

Answer 2

tacrine
donepezil
rivastigmine
galantamine

Question 3

acetylcholinesterase inhibitors MOA

Answer 3

central acting
reversible inhibition of ACh-esterase
-> inc. ACh

Question 4

tacrine AE

Answer 4

inc. LFT

Question 5

donepezil AE

Answer 5

fewest

Question 6

rivastigmine AE

Answer 6

HA

dizzy

Question 7

Galantamine AE

Answer 7

N/V

Question 8

donepezil administration

Answer 8

PO
ODT
- can be used for severe alzheimers

Question 9

rivastigmine administration

Answer 9

IR tab
patch
capsule

Question 10

galantamine administration

Answer 10

IR, ER, and liquid PO

Question 11

acetylcholinesterase inhibitors DI

Answer 11

cholinergic agonist: synergistic
anti-cholinergic: antagonistic
CYP 2D6, 3A4: dec. donepezil levels

Question 12

NMDA Rc antagonist

Answer 12

memantine

Question 13

memantine MOA

Answer 13

NMDA Rc antagonist

- regulates glutamate

Question 14

memantine use

Answer 14

alzheimers: moderate-severe

Question 15

memantine AE

Answer 15

GI intolerance
HTN
dizzy
HA

Question 16

memantine precaution

Answer 16

50/50 hepatic/renal excretion