Lower Airway Disease in Cats Flashcards

1
Q

What is the signalment of lower respiratory disease in cats?

What is it liekly to be in young versus older cats?

A

Signalment

Lower airway disease tends to affect young adult to middle aged cats but can affect cats of any age

Older cats-increases suspicion for other disease such as

  • hyperthyroidism
  • neoplasia
  • cardiac disease

Younger cats and kittens-increases suspicion for

  • infectious disease
  • viral
  • parasitic
  • Mycoplasma
  • bacterial
  • toxoplasma

**Bacterial pneumonia is relatively uncommon in cats compared with dogs**

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2
Q

What is the clinical history for lower respiratory track disease in cats?

A

Clinical History

Usually a low grade chronic disease

  • coughing

What does a coughing cat look/sound like?

  • audible wheezing
  • “exercise intolerance”

Sometimes a very acute presentation

  • brought in as an emergency
  • respiratory distress
  • mouth breathing
  • tachypnoea

Episodic respiratory distress

  • self limiting?
  • respiratory effort?
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3
Q

What questions should we ask?

A

What questions should we ask?

  • Are there any trigger factors?
  • Change in environment?
  • New cat litter?
  • Passive smoking?
  • Seasonal?
  • Is the cough productive?
  • Is anything “brought up”?
  • Often confusion with hair balls
  • Any significant weight loss, anorexia?
    *
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4
Q

Is it an acute or chronic disease in cats?

A

Cats are excellent at masking their clinical signs

  • quieter?
  • staying in bed all day?
  • less playful?
  • grooming less?
  • staying at floor level/reluctant to jump up on furniture?
  • An emergency presentation doesn’t always mean an acute disease
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5
Q

Look at this schematic for lower airway disease in cats?

A
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6
Q

How to assess your patient/is it critical?

A

Assessing the cat: how critical is your patient?

Respiratory reserve often minimal

Sympathetic stimulation –> counterproductive (HR goes up and Oxygen requirement increases) caused by:

  • transport
  • waiting room
  • is it “cat friendly”?
  • physical exam

Initial assessment should be hands off

Triage emergency patients

  • Are there trained staff empowered to make decisions?
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7
Q

What does the START anacronym stand for?

A

Simple Triage and Rapid Treatment

Treatment is often selected on a risk/benefit basis-if the risk is low and the benefit is high (eg supplementing oxygen) then the decision to treat is straightforward ” Prioritise oxygenation… START: simple triage and rapid treatment

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8
Q

How to assess respiratory pattern?

A

Respiratory pattern:

  • watch and listen
  • try to localise disease
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9
Q

Discuss the upper airway disease in terms of laryngeal disease?

A

Laryngeal disease

Laboured inspiration

stridor

↑ effort

slow inspiratory phase

+/-change in

  • purr
  • Vocalisation
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10
Q

Upper airway disease check for signs of?

A

Check the clinical history for signs of

  • Dysphagia +/-salivation
  • Coughing /gagging
  • might be triggered by eating/drinking
  • “Head shaking” behaviour
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11
Q

Signs of lower airway disease?

A

Lower airway disease: often more subtle

Laboured expiration

  • prolonged expiratory phase
  • additional expiratory push
  • audible expiratory wheeze

↑ airway resistance due to

  • bronchospasm
  • mucous
  • bronchial wall thickening

+/-occasional –> paroxysmal cough

  • owners may think “fur ball”
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12
Q

Discuss physical exam with regards to lower respiratory track disease?

A

Physical Examination

Can be deceptively normal

  • rule out other diseases?

Auscultation:

quiet room

listen for an expiratory wheeze

is the heart normal?

  • no murmur
  • no gallop rhythm
  • no tachycardia
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13
Q

What is the most common cause of LRT disease?

A

Inflammatory

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14
Q

What is feline asthma?

A
  • Reversible situation
  • Immune mediated process
  • Inhaled allergen
  • Airway hyper reactivity
  • Bronchoconstriction
  • Eosinophillic airway inflammation?

Signs: episodic respiratory distress and dyspnoea

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15
Q

What is chronic bronchitis?

A
  • Response to infection or inhaled irritants
  • Airway damage
  • Excess mucus
  • Neutrophilic airway inflammation?

Signs: Chronic coughing is a key feature

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16
Q

Discuss feline asthma and chronic bronchitis?

A

Currently…. without a better understanding of the aetiology of these two conditions, there is a lot of overlap in terms of presentationand treatment is essentially the same

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17
Q

Why do things spiral out of control in LRT disease?

A

Pathogenesis: why do things spiral out of control?

Hyper-reactivity of the bronchial smooth muscle

  • type I hypersensitivity reaction
  • autonomic imbalance
  • mucociliary imbalance (loss of function in the mucociliaryclearance systems)

Acute bronchoconstriction in response to a trigger factor

Inflammation of bronchial mucosal lining

  • histamine and leukotriene release
18
Q

Pathogenesis of LRT disease?

A

Airway obstruction occurs due to

  • bronchoconstriction
  • inflammation
  • mucus in narrowed bronchioles

Air trapping because the lungs cant empty –> destruction of alveoli due to hyper inflated lung

End result is chronic damage

  • irreversible situation due to remodelling
  • may see spontaneous rib fractures

Extreme acute deterioration

  • rare cases develop pneumothorax
  • chronic airway disease in cat in crisis can mimic/appear like an RTC
19
Q

What are some differential diagnoses for coughing in cats?

A
  • Upper respiratory tract disease
  • Inflammatory lower airway disease
  • Most likely thing we will see in cats that are coughing
  • Infectious – bacterial, viral, parasitic
  • Foreign body
  • Neoplasia
20
Q

What are some differential diagnoses for hyperpnoea/tachypnoea (increased effort and rate)?

A
  • Stress/pain/fear response - common response in cats
  • mouth breathing
  • CNS disease
  • Anaemia/hypovolaemia
  • Heatstroke
  • Cardiac disease
  • Respiratory disease
  • airways
  • lung parenchyma
  • Pleural space disease
  • In cats, they have a range of reasons for getting pleural effusion/fluid
  • Mediastinal disease
  • Cats like to get lymphoma
  • Ruptured diaphragm
  • Cars etc.
21
Q

To investigate lower airway disease we need to formulate a safe diagnostic plan.

What are some things you would like to do?

A
  • Haematology and biochemistry
  • what should we look for?
  • Hypereosinophilic syndrome?
  • Anaemia of chronic disease?
  • Biochemistry – not always that helpful in a coughing cat
  • Diagnostic imaging
  • radiography?
  • ultrasound?
  • advanced imaging?
  • CT/MRI
  • Bronchoscopy?
  • +/- bronchoalveloar lavage – can be more targeted, but it’s a luxury we cannot always achieve in cats. We might be able to pop a catheter down the trachea and see if we can get anything back so we can send off for cytology and culture
  • Can be useful, but not usually first line approach in coughing cats
  • Endotracheal wash?
  • Faecal analysis for parasites
22
Q

When should we consider a treatment trial in cats with LRT disease?

A
  • investigations at this stage are considered too risky?
  • some owners are especially risk averse…
  • owners cannot afford any diagnostics

Reaching a diagnosis is a luxury in some cases….

very often we just need to work with what we have.

History and physical exam are so important!

23
Q

How should we go about planning for radiographs in cats with LRT disease?

What are we looking for?

A

Rule out other causes of coughing and dyspnoea

  • Preoxygenate, never the wrong thing to do!
  • GA –but only if stable
  • Thoracic radiographs
  • might be normal
  • 20% of cats?
  • bronchial pattern
  • +/- interstitial
  • hyperinflation
  • air trapping
  • collapse of R middle lung lobe? Worst lung lobe, aspirates
  • patchy alveolar pattern?
  • Aerophagia -> air in stomach
24
Q

Why si GA often preferred to sedation when radiographing a cat with LRT disease?

A

Why is a GA preferred to sedation when we want to radiograph a cat with suspected airway disease? GA is better because you have got control of the airway, don’t want to have a sedated cat where respiratory effort is reduced and no control over the airways. With GA, can have full control and is often shorter acting

25
Q

What do you see on this radiograph?

A

evidence of hyperinflation, quite a gap between diaphragm and caudal border of the heart. Normally would be closer together – this separation is often a hallmark of hyperinflation which is what we are looking for supportive evidence with inflammatory airway disease

26
Q

When trying to rule out other causes of coughing and dyspnoea you could try bronchoscopy.

What are you lookig for?

What are some risks?

A
  • Bronchoscopy
  • hyperaemia
  • oedema
  • excess mucus
  • ↓ airway diameter
  • Think about the risks
  • aggravating irritable airways
  • moving plugs of mucus
  • bronchospasm
27
Q

When trying to rule out other causes of coughing and dyspnoea you could try a BAL.

What are you looking for?

What would you do with the sample?

A
  • BAL/blind tracheal wash
  • cytology
  • interpretation difficult
  • DDx for eosinophilic inflammation include
  • viral pneumonia
  • parasitic
  • HES - hypereosinophilic syndrome
  • bacterial culture
  • Mycoplasma PCR
28
Q

This is a BAL from a cat with CHF.

What can you see?

A
  • Perl’s stain showing positive for iron (haemosiderin) in the macrophages
  • Known as “heart failure cells” – don’t want to do a BAL on a cat with suspected heart failure!
  • Feature of chronic congestion
  • Reviewing the history for this 14 year old MN DSH cat who was referred for further investigations: he had lost some weight, was quiet and less keen to eat but not coughing. Physical examination revealed a heart rate of 250 (at rest) and tachypnoea (RR 38). Auscultation revealed a gallop rhythm and a systolic murmur (grade III/VI). We should not have airway disease at the top of the list of differentials for a cat like this
29
Q

What is some treatment you would use in a crisis in a cat with LRT disease?

A
  • Oxygenate
  • Manage inflammation
  • dexamethasone iv – potent anti-inflammatory drug
  • Manage bronchospasm
  • Terbutaline – bronchodilator for use in critical cases in cats
  • selective β2 receptor agonist
  • smooth muscle relaxant
  • bronchodilation
  • ideally rule out heart disease 1st
  • inhaled salbutamol
  • selective β2 receptor agonist
  • can give every 30 mins for 2-4 hrs
  • stop if stresses the patient
30
Q

What is salbutamol?

A
  • inhaled salbutamol
  • selective β2 receptor agonist
  • can give every 30 mins for 2-4 hrs
  • stop if stresses the patient

To help manage bronchospasm

31
Q

What is terbutaline?

A
  • Terbutaline – bronchodilator for use in critical cases in cats
  • selective β2 receptor agonist
  • smooth muscle relaxant
  • bronchodilation
  • ideally rule out heart disease 1st
32
Q

What are some longer term treatments for cats with LRT disease?

A
  • reduce allergens?
  • prednisolone po 2-3 weeks
  • consider inhaled fluticasone if improved
  • studies have confirmed route of delivery works
  • some oral ingestion
  • if no response to pred
  • review case
  • repeat test for Mycoplasma/or treat?
  • have we ruled out lungworm?
  • consider ciclosporin
33
Q

If a cat is not responding to pred, what should you do?

A
  • if no response to pred
  • review case
  • repeat test for Mycoplasma/or treat?
  • have we ruled out lungworm?
  • consider ciclosporin
34
Q

What are some risks of cats on steroids?

A

Risks: steroids are diabetogenic in cats. If side effects include polydipsia and polyuria treatment must stop!

35
Q

What is Aeleurostrongylus abstrusus?

A

Feline lungworm

36
Q

Aeleurostrongylus abstrusus:

What is the PPP?

What is the clinical presentation?

A
  • PPP 1-2 months
  • Most infected cats are asymptomatic
  • Clinical presentation
  • usually young cats
  • mild coughing but might à dyspnoea
  • radiography: similar to inflammatory airway disease
37
Q

What is the diagnosis and treatment of Aeleurostrongylus abstrusus in cats?

A
  • Diagnosis:
  • consider faecal flotation
  • airway wash analysis
  • Treatment trial: fenbendazole
38
Q

What is Mycoplasma pneumonia associated with?

What are clinical signs?

A
  • M felis associated with lower airway disease in cats
  • might also cause URT signs
  • Not all infections are significant
  • might be a contributing factor in feline inflammatory airway disease
  • Clinical signs: fever, cough, tachypnoea, lethargy
39
Q

What is the diagnosis and treatment of Mycoplasma pneumonia?

A
  • Diagnosis: PCR on tracheal wash
  • Treatment: doxycycline – a good treatment for mycoplasma but also has some good immune modulation properties, so has some anti-inflammatory effeccrts
  • Encourage swallowing after dosing orally, gently syringe some water after - can cause oesophageal strictures
40
Q

Why should you encourage swallowing after administration of doxycycline?

A

Encourage swallowing after dosing orally, gently syringe some water after - can cause oesophageal strictures

41
Q

What are some early cutaneous signs of Mycobacterial Pneumonia?

A
  • Early cutaneous signs:
  • after bite from an infected vole or rodent
  • non-healing sores or nodules +/- large LNs
42
Q

What are some early GI signs of Mycobacterial Pneumonia?

What is the diagnosis?

A
  • Early GI signs:
  • after ingestion eg contaminated milk
  • vomiting, diarrhoea, weight loss, poor appetite
  • lesion = inflammatory granulomas
  • Diagnosis: histopath and PCR- seek advice because we need to consider zoonotic aspects