Collapse, Weakness, Exercise Intolerance Flashcards

1
Q

What is the problem with a ‘collapsing’ patient?

What is important for you to spend enough time doing?

A
  • Patient is often “normal” at presentation.
  • Differential diagnosis list is huge -collapse, weakness, syncope, fainting, fits, seizures, funny turns etc,etc,etc.
  • SIGNALMENT.
  • HISTORY AND OWNER’S DESCRIPTION OF THE EVENTS IS VITAL, TAKE YOUR TIME.
  • FULL GENERAL HISTORY –OFTEN BEST LEFT UNTIL AFTER DESCRIPTION OF THE EVENT.
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2
Q

What kind of information do you want to get from a history?

A
  • Full general history –do first?
  • Then full description of episode(s)
  • History –should identify episode as:
    • Syncope (faint)
    • Seizure
    • Episodic weakness
  • Number of events
  • Age at onset
  • Duration
  • Time of day
  • Association with:
    • Exercise/excitement - If after exercise –more likely cardiorespiratory disease
    • Feeding
    • Rest/waking If after just woken up, far more likely to consider seizure
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3
Q

If collapse is associated woth exercise/excitement - which body system is most likely to be affected?

A

More likely to be cardiorespiratory

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4
Q

If collapse is associated with rest/waking - which body system is most likely to be affected?

A

If after has just woken up, far more likely to consider seizure

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5
Q

What are some more specific things you should ask about the history with a collapsing patient?

A
  • All the same –specific, predictable?
  • Prodrome/post ictalbehaviour
  • Tonic/clonic or flaccid
  • Autonomic signs –Has it lost control of bladder or defecate at the time?
  • Consciousness lost?
  • MM pallor/cyanosis
  • Heart rate
  • Normal between episodes –e.g. ex tolerance
  • Medication –any response/cause of episode
  • Toxin/drug access
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6
Q

What are some significant findings you are looking for in a patient that has collapsed previously?

A
  • Significant findings??
    • MM pallor
    • Dysrhythmia
    • Heart murmur
    • Neurological abnormality
    • Musculoskeletal abnormality

Significant findings may not always be relevant to the epidoes its having

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7
Q

After physical exam and moving onto diagnostic tests in a collpasing patient, what is done next?

A

What is done next is determined by:

  • Findings on physical examination
    • Pursue clinical abnormalities
    • Pursue breed-specific abnormalities?
  • RISK –breed associated disease?
  • Severity and/or frequency of episodes
  • Financial constraints
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8
Q

Define syncope

A
  • Sudden, short-lived loss of consciousness
  • Temporary failure of delivery of energy substrate to CNS - Oxygen and glucose in the blood, failure to thebrain
  • Typically failure of perfusion
    • ?? 6 seconds+
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9
Q

What are some clinical signs of syncope?

A
  • Sudden onset
  • Generalised weakness/ataxia
  • Flaccid collapse -motionless
  • Consciousness lost
  • Maybe autonomic signs
  • Maybe generalised mm activity
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10
Q

What are some differential diagnoses for syncope relating to inappropriate vascular reflexes?

A
  • Inappropriate vascular reflexes –will be clinically quite normal!
    • Vasovagal
    • Carotid sinus
    • Situational e.g. tussive
    • BP falls
    • perfusion fails
    • Clinically normal?
    • Lots of boxers faint
    • Often associated with excitement
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11
Q

What are some cardiac differential diagnoses for syncope?

A

Cardiac

  • Dysrhythmia
  • Flow obstruction
  • Pump failure
  • Tamponade/preload failure
    • Effusion can cause tamponade
  • Perfusion fails
  • Clinical abnormality likely
  • Exertional?
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12
Q

What are some non-cardiac differential diagnoses for syncope?

A

Non-cardiac

  • Metabolic
    • Non-motorseizure so no obvious tonic clonic signs
  • Central neurological
  • Clinical abnormality?
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13
Q

What are some diagnostic tests you can perform when you have suspected syncope in a patient?

A

The underlined ones are the highest yield tests, especially if the animal is clinicallynormal

  • Haematology and clinical biochemistry
  • ECG
    • 24 hour/event recorder/monitor
  • Thoracic/abdominal radiography
  • Echo
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14
Q

What is wrong with this ECG? Patient presented with syncope

Is this animal going to collapse?

A

Ventricular tachycardia, almost ventricular flutter

is this animal going to collapse? YES - heart will be going so fast it will not be able to fill properly

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15
Q

Describe findings on this ECG of a patient that presented with syncope

Why does the ECG go off the paper at one point?

A
  • Normal sinus rhythm
  • Then goes into complete heart block
  • P waves without QRS
  • Escape beats
  • ECG goes right up as the cat fell over
  • This cat has COMPLETE HEART BLOCK
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16
Q

If you have a patient with episodes of syncope, and there are no findings on an ECG - what should you do?

A

Monitor

Try to re-record ECG during profound collapse

17
Q

If you have a patient with episodes of syncope, and there are positive findings on the ECG but there is unknown significance to the episodes - what should you do?

A

Monitor

18
Q

What is wrong with this ECG?

A

Supraventricular tachycardia

19
Q

Describe findings on this ECG

A

Wide and bizarre complexes

Ventricular complexes

20
Q

Describe what the arrow is pointing at here on this ECG

A

Inverted P waves

Sinoatrial node disease

21
Q

Define episodic weakness

What does it worsen and improve with?

A
  • Intermittent/persistent exercise intolerance
  • Worsens with exercise
  • Improves with rest
22
Q

What are some differential diagnoses for episodic weakness?

A
  • Muscular
  • Neuromuscular
  • Orthopaedic
  • Respiratory
  • Cardiac
  • Metabolic
23
Q

What are some different diagnostic tests you should consider for different differentials for episodic weakness?

A
  • For metabolic disease
    • ACTH/TSH/insulin levels etc
  • For neuromuscular disease
    • Edrophonium respose test/anti Ach Ab
  • For muscular disease
    • EMG, mm biopsy
  • For cardio-respiratory disease
    • As discussed
    • Blood gases
24
Q

What are the 3 things seziures can break down into?

A
  • Extracranial disease
  • Structural intracranial disease
  • Functional intracranial disease
25
Q

What are some things that can cause extracranial disease?

A
  • Toxins
  • Metabolic disease
    • Hypoglycaemia
    • Hepatic disease
    • Severe uraemia
    • Hypocalcaemia
26
Q

If you think you have structural intracranial disease with seizures, what diagnostic tests should you think about doing?

A
  • CSF analysis
  • Skull radiography
  • CT or MRI
    • Want to rule out structural diseases within the brain
  • Functional intracranial disease
    • EEG?
27
Q

If the episodes of collapse/weakness/exercise introlerance are infrequence and/or benign, what should you do going forward?

A
  • Reassurance –this is good news
  • Monitor
  • Train owner to do the following:
    • Heart rate
    • MM
    • Video –get to see the circumstances in which the animal is doing what the owner says its doing
28
Q

You can go on a fishing trip if you find nothing of significance with regards to collapsing patients, what kind of things could you do?

A
  • Try and induce
  • Typically exercise-related problem
    • BS before and after
    • ECG before and after (during)
    • Take temperature
  • Haematology & clinical biochemistry
    • Inc mm enzymes
    • Inc electrolyte levels
    • Timing w.r.t feeding
  • ECG +/-monitoring
  • Radiography
29
Q

If there is NAD with collapsing patients, and nothing can be found - what is the prognosis?

A
  • Collapse, syncope, ex intolerance
  • No obvious diagnosis
  • Long term follow up
  • Very good prognosis likely!!!
30
Q

Dogs seem to fall into 4 groups when there is NAD with collapse/wekaness/exercise intolerance etc - what are they?

A
  1. Syncope
  2. Collapse, no consciousness loss ONLY with exercise/excitement
  3. Collapse, no consciousness loss NOT only with exercise/excitement
  4. TENOD –tires easily, no obvious diagnosis
    1. Dogs that don’t exercise well
31
Q

What is hyperthermia?

Clinical signs?

A
  • Many breeds/ages
  • Is a cause of ex intolerance –variable severity
  • Worse on hot days
  • Pant excessively
  • Lay down
  • Rectal temperature 107 o F + -hugely high
  • Seek water/wet grass/shade
  • High blood lactate