Lec 9 Cell Cell Interactions Signaling & Activation

Question 1

best antigen presenting cells

Answer 1

dendritic

Question 2

recognition by helper t cells requires macrophages and is restricted by the blank products

Answer 2

class 2 mhc

Question 3

to get an immune response, both blank cells are required

Answer 3

T and B

Question 4

the 2 signals required for b cell activation

Answer 4

one from antigen, one from t helper cell (usually cd40)

Question 5

t and b cells cooperate and form a blank effect

Answer 5

synergistic

Question 6

steps in b/t cell interactions

Answer 6

1. recognition of antigen by B cells via surface ig
2. b cell presentation to t cells
3. t cell secretion of cytokines which promote b cell growth/differentiation

Question 7

icam stands for

Answer 7

cellular adhesion molecule

Question 8

icams are on the surface to hold these together during interaction

Answer 8

t/b cells

Question 9

central interaction of b and t cells occurs between these

Answer 9

TCR, MHC

Question 10

ligand for TCR

Answer 10

MHC + antigen

Question 11

activation of t cells is similar to b cells such as signaling cascades but the blank is different

Answer 11

antigen

Question 12

Th1 and Th2 are blank cells

Answer 12

cytokine secreting

Question 13

Th1 triggers blank response

Answer 13

cell mediated

Question 14

Th2 triggers blank response

Answer 14

antibody mediated