Lec 4 - Generation Of Antibody Diversity

Question 1

Three levels of antibody diversity

Answer 1

Antibody binding, isotype switch, membrane interactions

Question 2

Each b cell clones produces one unique set of blank and blank

Answer 2

Ig heavy chain, variable chain

Question 3

Different portions of an immunoglobulin molecule are encoded by different genes and different combinations of these genes contribute to diversity

Answer 3

Alternative theory

Question 4

Heavy and light chains are encoded by different blank

Answer 4

Genes

Question 5

Different variable region genes are combined with different blank region genes

Answer 5

Constant

Question 6

V regions are like interchangeable screwdriver blank

Answer 6

Tips

Question 7

Additional short segment of dna which in b cells is joined to the V DNA between the C and V dna segments during gene rearrangement

Answer 7

J segments

Question 8

This segment is involved in heavy chains gene rearrangement

Answer 8

D (diversity) segmnet

Question 9

Different blank segments of germline dna make different combinations

Answer 9

V,J,D

Question 10

Single base substitution in the germline V gene segments can also generate different aa which are called blank

Answer 10

Somatic mutations

Question 11

Any blank chain can combine with any blank chain

Answer 11

Light, heavy

Question 12

Summary of AB diversity

Answer 12

Ok

Question 13

B cells cannot change their own enzyme blank but can change their blank

Answer 13

Specificity, isotype

Question 14

Isotype switching is blank because we can go from a long Ig to short Ig like IgM to IgD but not the other way around

Answer 14

Irreversible

Question 15

Membrane bound Igs are mostly used as antigen blank on surface of cells

Answer 15

Receptors

Question 16

Secreted and membrane bound Igs differ in blank terminus of the blank chain

Answer 16

C, heavy

Question 17

R: a more chemically complex antigen is wanted because it can turn more things blank

Answer 17

On

Question 18

R: heavy chains can be changed by these segments

Answer 18

J and D segments

Question 19

Isotype switching is useful because different isotypes have different blank

Answer 19

Functions

Question 20

Everything in nature is made of repeating blank

Answer 20

Patterns