Lec 5 Major Histocompatibility Complex

Question 1

major histocompatibility complex is a region formed by genetic loci involved in blank

Answer 1

foreign tissue rejection

Question 2

mhc is central role in blank and blank immunity

Answer 2

cell mediated, humoral

Question 3

mhc class that binds endogenous Ag expressed on all nucleated cells

Answer 3

class 1

Question 4

mhc class that binds exogenous antigen. these molecules are only on antigen presenting cells

Answer 4

class 2

Question 5

mhc class that has soluble serum proteins

Answer 5

class 3

Question 6

mhc is involved in determining if we can take a blank

Answer 6

transplant

Question 7

mhc are highly blank which that there are many alternate forms of the gene which means it is difficult to find a match for things like a bone marrow transplant

Answer 7

polymorphic

Question 8

functional assay class of mhc mapping that is cell mediated lympholysis and complement mediated cytotoxicity

Answer 8

class 1

Question 9

functional assay class that is mixed lymphocyte reaction

Answer 9

class 2

Question 10

mhc class that has alpha and beta 2 microglobulin that looks like it is standing on one leg

Answer 10

class 1

Question 11

mhc class 1 is found on membranes of all blank cells

Answer 11

nucleated

Question 12

mhc class that is 2 polypeptide chains and both alpha and beta chain go through the membrane

Answer 12

class 2

Question 13

mhc class 2 is found on certain blank cells

Answer 13

immune/antigen presenting

Question 14

mhc class 3 are blank proteins and play blank role in antigen presentation

Answer 14

soluble, no

Question 15

mhc diversity is greater than blank

Answer 15

1 trillion

Question 16

both class 1 and 2 mhc are synthesized here

Answer 16

RER

Question 17

class 1 mhc has binding of antigen occurring in the blank

Answer 17

rer

Question 18

class 2 mhc has binding of antigen occuring in the blank

Answer 18

lysosome

Question 19

differences between immunoglobulins and t cell receptors

Answer 19

t cell receptors are never secreted and only exist on surface, no somatic mutation

Question 20

most t cell receptors are blank

Answer 20

alpha beta

Question 21

these t cell receptors are peripheral blood cells

Answer 21

gamma, delta

Question 22

v and j variable regions are blank

Answer 22

alpha

Question 23

vjd variable regions are blank

Answer 23

beta

Question 24

t cell selection that is a self antigen and mhc reactive cells are induced to die

Answer 24

negative selection

Question 25

t cell selection that is when t cells with tcr that can easily interact with one or more self mhc moleucles are allowed to mature

Answer 25

positive selection

Question 26

all mature b cells express blank and blank

Answer 26

igM, igD

Question 27

b cells lose surface ig when they become blank

Answer 27

plasma cells

Question 28

antigen binding to mIg alone is not sufficient to induce blank proliferation

Answer 28

b cell