*Lec 9-2 - Inflammation Modulators & Mechanisms Flashcards
sequence of inflammation
errythema, cytokine release (pain), cell endothelial cell activation, adhesion of leukocytes, edema
neuropeptides activate blank
mast cells
mitochondrial peptides, membrane phospholipids both activate blank
macrophages and dendritic cells and complement
TLR activation activates these
mast cells, neutrophils, macrophages
TNF alpha, IL17, IL1 are important because
clinicians focus on acting on these
TLR2 binds cell wall components of blank bacteria
gram negative
TLR4 binds cell wall components of blank bacteria
gram positive
cytokines and chemokines are secreted by blank in response to bacteria
macrophages/dendritic cells
IL 6 leads to blank
fever/acute protein production
tnf alpha leads to
fever and shock
IL 1 Beta leads to
fever production of IL6
these can also result in bacterial killing and tissue damage
fibroblasts
this part of cells has a reservoir of factors for cell proliferation, differentiation, activation, etc
extracellular matrix
leukocytes, chemokines are very important for blank
homing and where cells will go to
this is important for vascular permeability and muscle contraction
bradykinin
