Lec 8-2 - Autoimmunity

Question 1

immunity to self

Answer 1

autoimmunity

Question 2

two types of autimmunity

Answer 2

organ specific, systemic

Question 3

thyroid self antigens are attacked and involves cd4 t cells and delayed type hypersensitivity

Answer 3

hashimoto’s thyroiditis

Question 4

auto antibodies to kidney and usually against type 4 collagen

Answer 4

goodpasteur’s syndrome

Question 5

auto antibodies to pancreatic beta cells in islets of langerhans

Answer 5

insulin dependent diabetes mellitus

Question 6

progressive demyelination of nerves and is autoimmune

Answer 6

multiple sclerosis

Question 7

diseases caused by antibodies have no blank but has altered function

Answer 7

no tissue destruction

Question 8

hyperthyroid disorder that has antibodies against tsh receptor…. nervousness, weight loss, enlarged thyroid

Answer 8

grave’s disease

Question 9

grave’s disease can present with blank

Answer 9

bug eyes

Question 10

antibodies against ach receptor that has muscle weakening

Answer 10

myasthenia gravis

Question 11

autoimmune disease of exocrine tissue that affects mostly women, dry mouth and eyes, crocodile skin

Answer 11

sjogren’s syndrome

Question 12

10 times more common in woemn, kidney dysfunction, rashes, weakness, fever, high complement, butterfly rash

Answer 12

systemic lupus erythematosis

Question 13

chronic inflammation of joint that is more common in women and has antibodies to the fc region of igG

Answer 13

rheumatoid arthritis

Question 14

treating ra is done by blank

Answer 14

blocking tnfalpha

Question 15

defects in molecules that inactivate blank can cause autoimmunity

Answer 15

t cells

Question 16

inhibitory receptor on t cells that downregulates t cell signaling response

Answer 16

ctla4

Question 17

loss of blank cells and inhibitory cytokines may contribute to autoimmunity

Answer 17

T regs

Question 18

b cell way of autoimmunity

Answer 18

failure of b cell tolerance

Question 19

blank cells play a major role in downregulating autoimmunity

Answer 19

th17

Question 20

genetic components to autoimmune diseases

Answer 20

mhc loci, hla

Question 21

percentage of autoimmune diseases that occur in women

Answer 21

90

Question 22

corticosteroids, cyclophosphamide are both blank

Answer 22

generalized immunosuppresants

Question 23

targeted therapy that kills activated t cells only

Answer 23

cyclosporine a

Question 24

women are more susceptible to autoimmune diseases because they are built to tolerate blank

Answer 24

foreign objects like babies