Lec 8-2 - Autoimmunity Flashcards
immunity to self
autoimmunity
two types of autimmunity
organ specific, systemic
thyroid self antigens are attacked and involves cd4 t cells and delayed type hypersensitivity
hashimoto’s thyroiditis
auto antibodies to kidney and usually against type 4 collagen
goodpasteur’s syndrome
auto antibodies to pancreatic beta cells in islets of langerhans
insulin dependent diabetes mellitus
progressive demyelination of nerves and is autoimmune
multiple sclerosis
diseases caused by antibodies have no blank but has altered function
no tissue destruction
hyperthyroid disorder that has antibodies against tsh receptor…. nervousness, weight loss, enlarged thyroid
grave’s disease
grave’s disease can present with blank
bug eyes
antibodies against ach receptor that has muscle weakening
myasthenia gravis
autoimmune disease of exocrine tissue that affects mostly women, dry mouth and eyes, crocodile skin
sjogren’s syndrome
10 times more common in woemn, kidney dysfunction, rashes, weakness, fever, high complement, butterfly rash
systemic lupus erythematosis
chronic inflammation of joint that is more common in women and has antibodies to the fc region of igG
rheumatoid arthritis
treating ra is done by blank
blocking tnfalpha
defects in molecules that inactivate blank can cause autoimmunity
t cells
inhibitory receptor on t cells that downregulates t cell signaling response
ctla4
loss of blank cells and inhibitory cytokines may contribute to autoimmunity
T regs
b cell way of autoimmunity
failure of b cell tolerance
blank cells play a major role in downregulating autoimmunity
th17
genetic components to autoimmune diseases
mhc loci, hla
percentage of autoimmune diseases that occur in women
90
corticosteroids, cyclophosphamide are both blank
generalized immunosuppresants
targeted therapy that kills activated t cells only
cyclosporine a
women are more susceptible to autoimmune diseases because they are built to tolerate blank
foreign objects like babies
