Lec 11 Complement Flashcards
complements help blank with lysis of bacteria
antibody
these can by lysed
gram negative bacteria and rbc
gram positive cells are not lysed but they are blank
opsonized
complement leads to blank
inflammation
three complement pathways
classical, lectin, alternative
the only complement with the b getting ripped off because usually a gets ripped off
c2
a component with enzyme activity affecting the next piece
convertase
c3 convertase
c4bc2a
classical pathway involves these
c1,c4,c2
alternative pathway involves these
factor b, d, p
lectin pathway involves these
mbl, masp2, c4, c2
pathway that can work without an antibody
alternative, lectin
lectin pathway needs blank
sugar
c1q in classical pathway requires blank
calcium
convertase at the end of classical
c3
alternative pathway doesnt involve blank activation
antibody
stabilizer of alternative
properdin
end of alternative pathway
c3 convertase
adding c3b to c3 convertase creates blank
c5 convertase
lectin pathway is like classical pathway but instead of having c1q, there is blank
MBL and SF
MBL and SF blank just like c1q
require calcium
c5-c9 complex is aka blank
membrane attack complex
c5a, c3a, c4a are all blank
anaphylotoxins
c3b, c4b, iC3b, c1q are all blank molecules
opsonic
increase in c5-c9 causes blank
inflammation/coagulation
factor 1, c1 inhibitor, daf, cr1 are all blank
complement regulators
factor b and d blank alternative pathway
activate it
factor h and I blank alternative pathway
inhibit it
inhibitor of lectin pathway
c1INH
c1inh deficiency is important for dentists because it can cause severe blank
edema
measure the amount of each protein using traditional serologic assays
antigenic assay
lytic function of the components is measured
functional assay
functional assay or antigenic assay is better
functional
low complement levels may mean blank
autoimmunity/genetic deficiency
this complement deficiency affects all pathways
c3
alternative pathway deficiency
pus infection
paroxysmal nocturnal hemoblobinuria is deficiency in blank
daf
c1,c4, c2 deficiency increases risk of this
autoimmune ct disease
lectin pathway deficiency increases bacterial infections in blank
infants
