Lec 12-2 - Immunodeficiency

Question 1

absence of thymus and cardiac abnormalities

Answer 1

digeorge syndrome

Question 2

immunodificiency that interferes with stem cell development into neutrophil, monocyte, etc

Answer 2

primary

Question 3

defective antibody response increases susceptibility to blank

Answer 3

pyogenic infections

Question 4

defective cell mediated immunity increases susceptibility to blank

Answer 4

opportunistic infections

Question 5

hereditary complement deficiencies lead to susceptibility to infections like this

Answer 5

neisseria

Question 6

defects in phagocyte functions leads to defects in blank pathways

Answer 6

oxygen reduction

Question 7

leukocyte adhesion deficiency would affect these

Answer 7

cell migration to infection sites

Question 8

x linked scid most common type affects this

Answer 8

gamma chain of IL2

Question 9

IL2 deficiency only causes a mild immunodeficiency but receptor KO has a severe phenotype because there are blank receptor subunits in the IL2 receptor family

Answer 9

shared

Question 10

SCID X1 is the failure of these cells to develop

Answer 10

t, nk

Question 11

deficiency of this molecule leads to defect of t cell signalizing

Answer 11

zap70

Question 12

most common immunodeficiency

Answer 12

igA deficiency

Question 13

igA deficiency is treated by these

Answer 13

replacing missing protein, replacing missing cell type, replacing missing or defective gene

Question 14

nude mice are involved in cancer research and have a blank

Answer 14

vestigial thymus

Question 15

major reservoir of hiv viral particles

Answer 15

lymphoid tissue

Question 16

hiv infects cells that have these 2 receptors

Answer 16

ccr5, cxcr4

Question 17

hiv causes progressive loss of these cells

Answer 17

cd4 helper t cells

Question 18

evidence of infection with hive

Answer 18

seroconversion

Question 19

these inhibit hiv infection by competing for coreceptors

Answer 19

chemokines

Question 20

scid mice have an absence of blank b and t cells in secondary lymph organs

Answer 20

mature

Question 21

genes that are mutated in scid mice that normal control vdj arrangement

Answer 21

rag1, rag2

Question 22

hiv is hard to treat because it blank into the hosts genome and it blanks the immune system

Answer 22

integrates, evades