Lec 7 Humoral Immunity Flashcards
primary response has blank b cell activation, main isotype is blank, and the antigens are both thymic blank and blank
naive, IgM, dependent, independent
secondaryresponse has blank b cell activation, main isotype is blank, and the antigens are thymic blank
memory, IgG, dependent
progressive change in ig class of specific antibody
isotype switch
isotype switch is usually blank to blank
igM –> igG
isotype switching is dependent on blank cells
t
degree of blank is inversely related to dose of antigen and this is associated with igM to igG switch
affinity maturation
under low antigen conditions, b cells with blank affinity receptors for the antigen will bind it
high
for t dependent reaction of activating b cells these signals are needed
one from antigen, one from complement breakdown of antigens, one from helper t
B cell signals through receptor and co-receptor supplemented through T cell interactions and signals
t dependent
B cell signals through receptor and co-receptor amplified by multiple epitopes and more extensive surface immunoglobulin cross-linking
t independent
surface ig has a very short blank tail so it cannot promote blank
cytoplasmic, signals
2 signaling molecules that carry out signals through motifs on their tails
IgAlpha, IgBeta
Most receptors trigger signaling by blank of existing signaling molecules
post translational modification
blank are central as it relates to signaling kinases
protein tyrosine kinases
Phosphorylation of receptor cytoplasmic tails serves to blank signaling molecules around the receptors
recruit
