Lec 7-2 - Allergy / Hypersensitivity

Question 1

process that occurs in subjects previously exposed to an antigen and who developed an immune response to that antigen

Answer 1

sensitization

Question 2

type 1 hypersensitivity is blank mediated

Answer 2

igE

Question 3

type 2 is blank mediated

Answer 3

ab mediated cytotoxicity, NK, complement… cell bound

Question 4

type 3 is blank mediated

Answer 4

immune complex mediated (soluble)

Question 5

type 4 is blank

Answer 5

cell mediated… no immunoglobulin

Question 6

harmless antigens that can stimulate an igE response

Answer 6

allergens

Question 7

upon first exposure to allergen, large amounts of blank are produced

Answer 7

igE

Question 8

high affinity receptors for igE that bind ig# without the ig being bound to an antigen

Answer 8

FceRI

Question 9

these bind free circulating igE via the FceRI

Answer 9

mast cells and basophils

Question 10

this phase of allergic reaction is characterized by antigen binding and FceRI crosslinking

Answer 10

activation

Question 11

upon activation, mast cells and basophils immediately go through blank

Answer 11

degranulation

Question 12

contents of cellular granules are released into the surrounding environment

Answer 12

degranulation

Question 13

in this phase, preformed mediators stored in cell granules are released

Answer 13

early phase

Question 14

early phase response is responsible for the majority of severe clinical manifestations of blank

Answer 14

type 1 hypersensitivity

Question 15

synthesis and secretion of cytokines and chemokines occurs in this phase

Answer 15

late phase

Question 16

long lasting asthma that causes problems even in the absence of the original allergen

Answer 16

chronic asthma

Question 17

systemic anaphylaxis can cause a loss of blank and blank collapse

Answer 17

blood pressure, cardiovascular

Question 18

bee stings, peanuts, seafood, penicillin can all cause blank

Answer 18

systemic anaphylaxis

Question 19

hay fever, atopic dermatitis, asthma can cause blank

Answer 19

localized anaphylaxis

Question 20

many allergens cause igE production because they will be small and may have similar enzymes to blank which are what igE was made to respond to

Answer 20

parasites

Question 21

two skin tests for allergies

Answer 21

prick test, intradermal test

Question 22

allergic individuals have a higher level of blank igE and are more prone to blank cell stimulation

Answer 22

circulating, Th2

Question 23

small amounts of allergen are given to switch response from igE to IgG

Answer 23

hyposensitization

Question 24

transfusion reactions, hemolytic anemias, and antibodies are directed to tissue or cell surface antigens type of hypersensitivity

Answer 24

type 2

Question 25

type 2 hypersensitivity is directed by these antibodies

Answer 25

igG, igM

Question 26

in rhesus prophylaxis, anti rhD antibodies are given to the blank mother after delivering the blank baby

Answer 26

rh - , rh+

Question 27

complement is triggered by igG and igM in this

Answer 27

type 3 hypersensitivity

Question 28

type of sensitivity with cd4 and cd8 t cells involved

Answer 28

type 4 hypersensitivity

Question 29

examples of type 4

Answer 29

contact dermatitis, tuberculin reactions