Lec 12 - Cell Migration/Phagocytosis Flashcards
all leukocytes can do this which is preferential migration of cells so they “know” how to get back
homing
first line of defense
neutrophils
a biochemical event that causes an increase in oxidative metabolism of phagocytes following uptake of opsonized particles
respiratory burst
t cell migration crosses cells by blank
diapedesis
unlike lymphocytes, neutrophils make a blank journey from bone marrow to tissue
one way
main contributor to inflammation
neutrophil
main contributor to chronic autoimmune reactions
cd4 T cells
main contributor to asthma
eosinophils, basophils, macrophages
toll like receptors can recognize these
LPS, bacterial flagellin, viral ss/ds RNA, bacterial dna
two types of adhesion molecules
integrins, selectins
homing receptor in lymphocyte circulation
L selectin
mediates adhesion of memory t cells and nk cells and neutrophils in response to inflammation
e selectin
this is involved in blood clotting
p selectin
all beta integrins share this
cd18
defect in cd18 causes this
leukocyte adherence deficiency