Lec 6 Antigen Recognition, Processing, Presentation Flashcards
three antigen presenting cells
monocytes/macrophages, b cells, dendritic cells
dendritic cells present the antigen via blank
pinocytosis
cells that recognize antigen specifically
t cells, b cells
8-10 aa are recognized by blank
class 1
14-20 aa are recognized by blank
class 2
two types of t cells
cd4, cd8
cd4 t cells are blank t cells and recognize antigens in association with blank mhc molecules
helper, class 2
cd8 t cells are blank t cells and kill cells that present antigens. is a receptor for blank mhc molecules
cytotoxic, class 1
all cells of body present antigen to blank t cells
cd8
molecules which recognize a variety of structurally conserved molecules of microbes
TLRs
strong immunogens bind blank to mhc than weak immunogens
better
in the blank, class 1 and class 2 blank
segregate
class 1 goes directly to the blank after segregation
cell surface
class 2 goes to the blank after segregation
lysosomal like compartment
activation of a cd8 cell requires a blank secondary signal than those required for the activation of a cd4 cell
stronger
produced by pathogens ranging from bacteria to mammalian retroviruses
superantigens
superantigens bind to both mhc class blank molecules as well as tcr alpha beta simultaneously
2
superantigens stimulate most t cells that express a given blank sequence
alpha, beta
R: antigen recognition by blank cells is restricted by the blank so you cant take t cells from another person and expect them to work
t, mhc
R: know class 1 and class 2 inside and out
ok
