Lec 7-5 - HIV

Question 1

hiv destroys these cells

Answer 1

cd4+ t lymphocytes

Question 2

hiv 1 strains

Answer 2

M,O,N

Question 3

HIV2 comes from blank

Answer 3

monkeys

Question 4

this enyzme contained in the infecting virion converts positive stranded genomic rna into ds dna before going to the nucleus and integrating randomly into the chromosomes via a hiv blank

Answer 4

reverse transcriptase, integrase

Question 5

hiv binds via the high affinitiy blank protein to the receptor on the host cell surface, the cd4 molecule

Answer 5

gp120

Question 6

hiv1 must also bind to two coreceptors to actually enter the cell….called blank and blank

Answer 6

ccr5, cxcr4

Question 7

for a mature virus, blank is required to cleave polyproteins into proteins required for viral integrity

Answer 7

protease

Question 8

this gene is structural and requires cleavage by hiv protease

Answer 8

gag

Question 9

this gne is cleaved by cellular proteases… not hiv proteases

Answer 9

env

Question 10

not having ccr5 or cxcr4 can lead to blank

Answer 10

immunity from hiv infection

Question 11

as hiv progresses, it turns into aids and the immune system regulation wanes and the patient becomes more susceptible to blank and blank

Answer 11

infections, malignancies

Question 12

aids can change every base in hiv by chance alone in a blank time

Answer 12

very short

Question 13

infection in hiv is usually from things that blank would usually take care of with cell mediated immunity

Answer 13

t cells

Question 14

hiv progresses faster if blank

Answer 14

higher amount of circulating virus, low cd4 count