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Dental Microbiology > Lec 4-2 - Mucosal Immunity > Flashcards

Lec 4-2 - Mucosal Immunity Flashcards

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Biology 101 flashcards
1
Q

most frequent portal of infection

A

mucosa

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2
Q

tomasi showed that blank is the main ig in secretions

A

igA

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3
Q

most lymphocytes are here

A

gi tract

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4
Q

igA has a blank but not a blank

A

j chain, j segment

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5
Q

igA downregulates production of these

A

igG, igM

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6
Q

igA that is in serum and has a double y shape

A

sIga

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7
Q

j chain is synthesized by blank

A

plasma cells

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8
Q

ratio of j chain to ig polymer

A

1:1

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9
Q

secretory component of igA is synthesized by blank cells not blank cells

A

epithelial, plasma

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10
Q

secretory component of igA protects the ig from blank by intestinal enzymes

A

proteolysis

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11
Q

most important function of sIgA

A

inhibit adherence/uptake at mucosae

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12
Q

functional part of antibody

A

fc

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13
Q

genitourinary, tracheobronchial trats, and intestines all have this

A

sIgA

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14
Q

antigen transport and processing is done by this

A

MALT

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15
Q

these overlay peyer’s patches and transport antigens to the macrophage or dendritic cells

A

microfold cells

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16
Q

microfold cells lack blank molecules so they are not considered blank

A

mhc class 2, antigen presenting cells

17
Q

these are aka GALT and present antigens to lymphocytes

A

macrophage-like cells, dendritic cells

18
Q

iL5, IL4, 6,10,13 all promote blank synthesis

A

igA

19
Q

this increases igA secretion by b cells

A

tgfB1

20
Q

TGFB1 acts as an igA switch factor from blank to blank which decreases igG and igM secretion

A

igM, IgA

21
Q

cd20 is a marker for blank cells

A

b

22
Q

cd3 is a marker for blank cells

A

t

23
Q

b cell homing is independent of blank and appears to be blank

A

antigen, random

24
Q

secretory antibodies limit blank of protein antigens via mucosal membranes

A

absorption

25
Q

T cells presented with Ag peptides in the absence of co-stimulatory signals become refractory to further stimulation with Ag

A

anergy

26
Q

these cells actively suppress Ag-specific responses following re-challenge with Ag

A

regulatory t cells

27
Q

polio vaccine protects by blank at mucosa surfaces

A

sIgA

28
Q

mucosal vaccines prevent blank

A

entry of the pathogen

29
Q

difference between other immune responses and mucosal immunity is that the system gears itself into channeling a blank response

A

igA

30
Q

IgA is so important to the mucosa because it

A

prevents entry of pathogens

31
Q

helper t cells push igA response and downregulate these

A

igM, igG

Dental Microbiology (47 decks)

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