Lec 4-2 - Mucosal Immunity Flashcards
most frequent portal of infection
mucosa
tomasi showed that blank is the main ig in secretions
igA
most lymphocytes are here
gi tract
igA has a blank but not a blank
j chain, j segment
igA downregulates production of these
igG, igM
igA that is in serum and has a double y shape
sIga
j chain is synthesized by blank
plasma cells
ratio of j chain to ig polymer
1:1
secretory component of igA is synthesized by blank cells not blank cells
epithelial, plasma
secretory component of igA protects the ig from blank by intestinal enzymes
proteolysis
most important function of sIgA
inhibit adherence/uptake at mucosae
functional part of antibody
fc
genitourinary, tracheobronchial trats, and intestines all have this
sIgA
antigen transport and processing is done by this
MALT
these overlay peyer’s patches and transport antigens to the macrophage or dendritic cells
microfold cells
microfold cells lack blank molecules so they are not considered blank
mhc class 2, antigen presenting cells
these are aka GALT and present antigens to lymphocytes
macrophage-like cells, dendritic cells
iL5, IL4, 6,10,13 all promote blank synthesis
igA
this increases igA secretion by b cells
tgfB1
TGFB1 acts as an igA switch factor from blank to blank which decreases igG and igM secretion
igM, IgA
cd20 is a marker for blank cells
b
cd3 is a marker for blank cells
t
b cell homing is independent of blank and appears to be blank
antigen, random
secretory antibodies limit blank of protein antigens via mucosal membranes
absorption
T cells presented with Ag peptides in the absence of co-stimulatory signals become refractory to further stimulation with Ag
anergy
these cells actively suppress Ag-specific responses following re-challenge with Ag
regulatory t cells
polio vaccine protects by blank at mucosa surfaces
sIgA
mucosal vaccines prevent blank
entry of the pathogen
difference between other immune responses and mucosal immunity is that the system gears itself into channeling a blank response
igA
IgA is so important to the mucosa because it
prevents entry of pathogens
helper t cells push igA response and downregulate these
igM, igG
