Lec 6-2 Tumor Immunology and Immunotherapy

Question 1

epithelial tissue tumor

Answer 1

carcinoma

Question 2

ct tumor

Answer 2

sarcoma

Question 3

wbc tumor

Answer 3

leukemia, lymphoma, myeloma

Question 4

recurring tumors… antigens that were originally lost after embryo to adult development

Answer 4

oncofetal antigens

Question 5

tumor looks like tissue

Answer 5

differentiated

Question 6

tumor that doesnt look much like tissue

Answer 6

undifferentiated

Question 7

grade of cancer that is undifferentiated and therefore the worst

Answer 7

grade 4

Question 8

induced b cell lymphomas developed from taking immunosuppressents

Answer 8

epstein barr virus - burkitt lymphoma

Question 9

most human tumors are not blank

Answer 9

viral

Question 10

how a tumor can change its immunogenicity throughout its growth

Answer 10

immunoediting

Question 11

a checkpoint molecule that is a negative regulator of t cell proliferation

Answer 11

ctla-4

Question 12

immune surveillance is done by blank which kills tumors if they find them

Answer 12

t cells

Question 13

this will often prevent a tumor from being found by immune surveillance

Answer 13

immunoediting

Question 14

direct killing of tumor specific t cells is done by these cells

Answer 14

cd4, cd8

Question 15

component of class 1 molecule on all nucleated cells

Answer 15

beta 2 microglobulin

Question 16

afp is a tumor marker involved in staging these cancers

Answer 16

hepatoma, testicular

Question 17

afp l3 differntiates benign from malignant blank

Answer 17

liver cancer

Question 18

marker in breast cancer

Answer 18

ca 15-3 and ca 27-29

Question 19

marker for monitoryign pancreatic and bile duct cancers

Answer 19

ca 19-9

Question 20

marker for ovarian cancer

Answer 20

ca 125

Question 21

antigen used for staging… high at diagnosis means bad outlook

Answer 21

CEA

Question 22

antigen to id prostate cancer

Answer 22

PSA

Question 23

chemokines that attract Tregs in tumor progression

Answer 23

CCL22

Question 24

Tregs are good or bad for cancer

Answer 24

bad… means worse cancer

Question 25

variable heavy and light chain region that is distinguishing of a b cell

Answer 25

idiotype

Question 26

chimeric antigen receptor - t cell is made up of these

Answer 26

cd 3, and variable heavy and light chains of the antibodies

Question 27

chimeric antigen receptor t cell is advantageous because it is not blank

Answer 27

not toxic

Question 28

chimeric antigen receptor t cell cons

Answer 28

infections, more cancer… because t cells are pretty much shut down