Lec 6-2 Tumor Immunology and Immunotherapy Flashcards
epithelial tissue tumor
carcinoma
ct tumor
sarcoma
wbc tumor
leukemia, lymphoma, myeloma
recurring tumors… antigens that were originally lost after embryo to adult development
oncofetal antigens
tumor looks like tissue
differentiated
tumor that doesnt look much like tissue
undifferentiated
grade of cancer that is undifferentiated and therefore the worst
grade 4
induced b cell lymphomas developed from taking immunosuppressents
epstein barr virus - burkitt lymphoma
most human tumors are not blank
viral
how a tumor can change its immunogenicity throughout its growth
immunoediting
a checkpoint molecule that is a negative regulator of t cell proliferation
ctla-4
immune surveillance is done by blank which kills tumors if they find them
t cells
this will often prevent a tumor from being found by immune surveillance
immunoediting
direct killing of tumor specific t cells is done by these cells
cd4, cd8
component of class 1 molecule on all nucleated cells
beta 2 microglobulin
afp is a tumor marker involved in staging these cancers
hepatoma, testicular
afp l3 differntiates benign from malignant blank
liver cancer
marker in breast cancer
ca 15-3 and ca 27-29
marker for monitoryign pancreatic and bile duct cancers
ca 19-9
marker for ovarian cancer
ca 125
antigen used for staging… high at diagnosis means bad outlook
CEA
antigen to id prostate cancer
PSA
chemokines that attract Tregs in tumor progression
CCL22
Tregs are good or bad for cancer
bad… means worse cancer
variable heavy and light chain region that is distinguishing of a b cell
idiotype
chimeric antigen receptor - t cell is made up of these
cd 3, and variable heavy and light chains of the antibodies
chimeric antigen receptor t cell is advantageous because it is not blank
not toxic
chimeric antigen receptor t cell cons
infections, more cancer… because t cells are pretty much shut down
