Lec 2 - Immunoglobulins

Question 1

IgA vs IgE

Answer 1

Isotypes

Question 2

Different classes of immunoglobulins

Answer 2

Isotypes

Question 3

Small differences between individuals of same species in the amino acids… Ex) differences between IgA’s

Answer 3

Allotypes

Question 4

Most numerous immunoglobulin (85%) in serum of human

Answer 4

IgG

Question 5

IgG and IgM activate blank

Answer 5

Complement

Question 6

Fragments of Ig for binding

Answer 6

FAB

Question 7

Ig domain that is a region of heavy or light chain which by aa sequence remains unchanged in chains of the same type

Answer 7

Constant

Question 8

Ig domain that is a region that is not constant

Answer 8

Variable

Question 9

Segment of heavy chain between ch1 and ch2 domainst hat is a flexible segment of aa

Answer 9

Hinge region

Question 10

This is a long heavy chain that is much bigger than IgG and contains a joining chain and is the most convserved Ig

Answer 10

IgM

Question 11

First Ig in immune response and produce neonate

Answer 11

IgM

Question 12

This protects the Ig from proteolysis by intestinal enzymes

Answer 12

secretory component

Question 13

Secretory component facilitates the transport of secretory blank into secretions

Answer 13

IgA

Question 14

Major function of this Ig is to arm mast cells and basophils for their role in allergic reactions

Answer 14

IgE

Question 15

IgE does not activate blank

Answer 15

Complement

Question 16

Low concentration in serum and is difficult to study and acts as antigen receptor on b cells and does not activate complement

Answer 16

IgD

Question 17

IgA does not have a blank component

Answer 17

Secretory

Question 18

Know primary vs secondary organs

Answer 18

Ok

Question 19

Thymus eliminates blank percent of all t cells

Answer 19

95%

Question 20

Functions of IgG

Answer 20

Opsonize, agglutinate, bacterialyse

Question 21

IgA is in anything that is secreted like these

Answer 21

Saliva, breastmilk, mucous

Question 22

Antibodies were originally called blank

Answer 22

Gamma globulins