Lec 2-5 - Orthoinfluenza Flashcards
this has influenza viruses A & B
orthomyxoviruses
influenza serotypes that cause human illness
A/B
these are more ancient in humans and seem to have reached some equilibrium with us
B/C
influenza virus structure due to lipid bilayer not being rigid
pleomorphic
influenza virus has blank and blank peplomers
H, N
influenza A show a lot of variation in blank proteins but B and C do not
H, N
H is aka blank and is receptor binding protein for the virus and recognizes blank on the surface of a cell
hemagluttinin, sialic acid
N is aka blank and cleaves blank residues which is antagonistic to H… acts while the virus leaves the cell so it doesnt get stuck
neuraminidase, sialic acid
antigenic drift of influenza A is a blank change
minor (natural mutation)
antigenic shift is a blank change of influenza A
major (big change in the virus)
this often follows pulmonary influenza virus infection and has a bad prognosis
secondary bacterial pneumonia
fastest way to diagnose influenza virus
viral antigens
most sensitive way to diagnose influenza
PCR
lab diagnosis is by a blank fold rise in antibody titer
4
antiviral agents are active against blank via blank
both influenza A and B, neuraminidase inhibitors
