Lec 2-5 - Orthoinfluenza Flashcards
this has influenza viruses A & B
orthomyxoviruses
influenza serotypes that cause human illness
A/B
these are more ancient in humans and seem to have reached some equilibrium with us
B/C
influenza virus structure due to lipid bilayer not being rigid
pleomorphic
influenza virus has blank and blank peplomers
H, N
influenza A show a lot of variation in blank proteins but B and C do not
H, N
H is aka blank and is receptor binding protein for the virus and recognizes blank on the surface of a cell
hemagluttinin, sialic acid
N is aka blank and cleaves blank residues which is antagonistic to H… acts while the virus leaves the cell so it doesnt get stuck
neuraminidase, sialic acid
antigenic drift of influenza A is a blank change
minor (natural mutation)
antigenic shift is a blank change of influenza A
major (big change in the virus)
this often follows pulmonary influenza virus infection and has a bad prognosis
secondary bacterial pneumonia
fastest way to diagnose influenza virus
viral antigens
most sensitive way to diagnose influenza
PCR
lab diagnosis is by a blank fold rise in antibody titer
4
antiviral agents are active against blank via blank
both influenza A and B, neuraminidase inhibitors
these are active against influenza A ONLY
amantadine, rimantadine
anti neuraminidase agents work by blocking the site of blank but were not able to be metabolized by blank
sialic acid, neuraminidase
antibodies to HA stop blank
viral infection
antibodies to NA stop blank
replication/release
types of influenza vaccines
inactivated (TIV), live attenuated, recombinant HA
live attenuated vaccine is the same composition as TIV but composed of blank mutants
temperature sensitive
recombinant HA is good for those who have blank allergies
egg
