Lec 2-2 Control of the Immune Response Flashcards
5 mechanisms to regulate immunity
antigen blocking, receptor cross linking, passive regulation of ab affinity, immune complexes, idiotypic regulation
this is the competition for antigen with antigen receptors on b cells
antigen blocking
in antigen blocking, blank cover the antigen so the blank doesnt recognize it
antibodies, b cell
b cell differentiation is inhibited by blank antigen receptors with fc receptors on the b cells
cross linking
passive regulation for antibody affinity involve sequestering free antigen and only b cells with blank affinity receptors for the antigen will bind it
high
these are when the antigen and antibody are bound together
immune complex
immune complex cross linking augmentation occurs when blank crosslinks form between these receptors
fc receptors
inhibition occurs when blank receptors are crosslinked with blank
fc, antigen receptors
antigenic constitution of variable region of ig molecule
idiotype
antigenic determinants of which the idiotype is made up
idiotope
part of variable region which forms the antigen binding site
paratope
ab that recognizes idiotypic determinants of other ab… so abs become ags
antiidiotypic
antiidiotype abs that bind inside the ag combining site and will inhibit the ag from binding to that site
site associated antiidiotypes
antiidiotype abs that bind to antigenic determinants which are associated with the idiotype of an ig molecule but are not inside the ag combining site
non site associated antiidiotypes
antiidiotypic abs have their own blank so there are antibodies against them called blank
idiotypes, anti-anti-idiotypic antibodies
cells whose function is to regulate the immune system
regulatory t cells (suppressor t cells)
distinguishable characteristic of supressor t cells from helper/cytotoxic t cells
surface markers
proteins that remain in circulation, rather than those disposed of by the phagocytic system, tend to favor blank suppressor t cells
producing
conditions that favor suppressor t cells
type of ag, repeated administration of ag, route of ag administration, age of host
suppressor cells work by interacting with other cells, interacting with APCs, inhibiting secretion of blank, and suppressing idiotypic determinants
IL-2
t cell that becomes a major producer of cytokines
cd4
Il4 and interferon gamma inhibit development of blank cells
th17
response to antigen by a number of b cell clones that can be reacting via the same epitope or multiple epitopes
polyclonal response
costimulatory receptor on t cell that activates naive t cells
cd28
anti anti idiotypic regulated by anti anti anti….this is called the blank theory
network theory
network theory does/does not play a major role in antibody response
does not
