Lec 2-2 Control of the Immune Response

Question 1

5 mechanisms to regulate immunity

Answer 1

antigen blocking, receptor cross linking, passive regulation of ab affinity, immune complexes, idiotypic regulation

Question 2

this is the competition for antigen with antigen receptors on b cells

Answer 2

antigen blocking

Question 3

in antigen blocking, blank cover the antigen so the blank doesnt recognize it

Answer 3

antibodies, b cell

Question 4

b cell differentiation is inhibited by blank antigen receptors with fc receptors on the b cells

Answer 4

cross linking

Question 5

passive regulation for antibody affinity involve sequestering free antigen and only b cells with blank affinity receptors for the antigen will bind it

Answer 5

high

Question 6

these are when the antigen and antibody are bound together

Answer 6

immune complex

Question 7

immune complex cross linking augmentation occurs when blank crosslinks form between these receptors

Answer 7

fc receptors

Question 8

inhibition occurs when blank receptors are crosslinked with blank

Answer 8

fc, antigen receptors

Question 9

antigenic constitution of variable region of ig molecule

Answer 9

idiotype

Question 10

antigenic determinants of which the idiotype is made up

Answer 10

idiotope

Question 11

part of variable region which forms the antigen binding site

Answer 11

paratope

Question 12

ab that recognizes idiotypic determinants of other ab… so abs become ags

Answer 12

antiidiotypic

Question 13

antiidiotype abs that bind inside the ag combining site and will inhibit the ag from binding to that site

Answer 13

site associated antiidiotypes

Question 14

antiidiotype abs that bind to antigenic determinants which are associated with the idiotype of an ig molecule but are not inside the ag combining site

Answer 14

non site associated antiidiotypes

Question 15

antiidiotypic abs have their own blank so there are antibodies against them called blank

Answer 15

idiotypes, anti-anti-idiotypic antibodies

Question 16

cells whose function is to regulate the immune system

Answer 16

regulatory t cells (suppressor t cells)

Question 17

distinguishable characteristic of supressor t cells from helper/cytotoxic t cells

Answer 17

surface markers

Question 18

proteins that remain in circulation, rather than those disposed of by the phagocytic system, tend to favor blank suppressor t cells

Answer 18

producing

Question 19

conditions that favor suppressor t cells

Answer 19

type of ag, repeated administration of ag, route of ag administration, age of host

Question 20

suppressor cells work by interacting with other cells, interacting with APCs, inhibiting secretion of blank, and suppressing idiotypic determinants

Answer 20

IL-2

Question 21

t cell that becomes a major producer of cytokines

Answer 21

cd4

Question 22

Il4 and interferon gamma inhibit development of blank cells

Answer 22

th17

Question 23

response to antigen by a number of b cell clones that can be reacting via the same epitope or multiple epitopes

Answer 23

polyclonal response

Question 24

costimulatory receptor on t cell that activates naive t cells

Answer 24

cd28

Question 25

anti anti idiotypic regulated by anti anti anti….this is called the blank theory

Answer 25

network theory

Question 26

network theory does/does not play a major role in antibody response

Answer 26

does not