Lec 3-2 Self Recognition Flashcards
state of unresponsiveness specific for a particular antigen
tolerance
immune system still blank that it is tolerant to, it just doesnt blank
recognizes, react
we are not conceived knowing black vs blank
self vs non self
immunological self covers all blank encoded by an individuals dna
epitopes
relating to lymphocytes and epitope… time, site, nature, production are all factors for blank
induction
route to tolerance that is the physical deletion of lymphocytes from the peripheral repertoire
clonal deletion
route to tolerance that is the prevention of further differentiation of immature cells (these escaped deletion)
clonal abortion
downregulation of mechanisms of immunological response
clonal anergy
route to tolerance that are interactions with other cells and or inhibitory factors
continuous inhibition
two induction mechanisms of t cell tolerance
positive, negative
t cells that are selected because they can bind to mhc molecules
positive selection
t cells that are selected like undercover cops because they bind to mhc but are reactive to self antigens
negative selection
specialized cd8 cells that bear self epitopes and impart a negative signal to kill self reactive clone
veto cells
if an antigen gets past the thymus then it may not provoke a response… this is called blank even though it isnt technically a “tolerance”
post thymic tolerance
lack of self reactivity by B cells is probably due to lack of blank but blank
t cell help, not always
