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Dental Microbiology > Lec 8 - Cytokines > Flashcards

Lec 8 - Cytokines Flashcards

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Biology 101 flashcards
1
Q

one cytokine acts on multiple cells and has multiple functions

A

pleiotropic

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2
Q

two cytokines have same function

A

redundant

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3
Q

sum is greater than parts

A

synergistic

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4
Q

one cytokine blocks function of another

A

antagonistic

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5
Q

ctyokines are generally not blank

A

stable

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6
Q

acts on the cell that secreted it

A

autocrine

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7
Q

acts on a nearby cell

A

paracrine

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8
Q

enters circulation and acts at distant site

A

endocrine

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9
Q

cytokiens are just really involved in blank of all different types of immunity and hematopoiesis

A

regulation

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10
Q

These cytokines are produced by mononuclear phagocytes, stimulate early responses to microbes. These are indicators of an inflammation.

A

regulate innate immunity

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11
Q

Produced by T cells during specific immune response. Regulate activation and differentiation of cells involved in T-dependent immune responses

A

regulate adaptive immunity

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12
Q

il2 regulates blank proliferation

A

t cell

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13
Q

il4 and ifn gamma regulates blank

A

isotype switching

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14
Q

Produced by bone marrow and thymic stroma, stimulate development of specific lineages of immune cells

A

regulate hematopoiesis

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15
Q

cytokine receptors are usually blank or blank

A

dimers, multimers

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16
Q

therapeutic approach to treat Rheumatoid Arthritis

Psoriasis

A

TNF inhibition

17
Q

First found as growth factor for T cells, crucial step in allowing the study of T cells.
Plays a central role in T cell expansion and maintenance of T cell homeostasis
Critical for preventing autoimmunity

A

IL-2

18
Q

IL-2Ralpha is the blank and is not required for signaling

A

affinity modulator

19
Q

IL-2Rbeta is needed for blank

A

signaling

20
Q

t cells that recognize antigen are stimulated by blank concentrations of IL-2

A

low

21
Q

IL-2 kills blank t cells

A

activated

22
Q

IL-2 blank the immune response

A

downregulates

23
Q

without IL-2, we get severe blank diseases

A

autoimmune

24
Q

This is considered to be the first, clear-cut example of successful gene therapy

A

gamma C

25
Q

Most immune reactions are dominated by either populations and secrete different cytokines

A

Th1, Th2

26
Q

develop when the activated T cell is exposed to IL-12 (usually from the APC, esp. dendritic cells)

A

Th1

27
Q

develop when the activated T cell is exposed to IL-4 (from an unknown cellular source) (

A

Th2

28
Q

Th 1 also increases cell mediated blank

A

cd8 killing

29
Q

Th2 also increases the mediated blank

A

antibody killing

30
Q

Secreted proteins that regulate cell movement and recruitment

A

chemokines

31
Q

chemokines can be related in these

A

adhesion, shape changes, chemotaxis

Dental Microbiology (47 decks)

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