Lec 11-2 - Pharm Manipulation

Question 1

methotrexate is specific for the blank phase of division

Answer 1

S

Question 2

mechanism of action of steroids

Answer 2

lipid soluble compounds diffuse across cell membranes and bind cystolic receptors, dimer of heat shock protein displaced, exposing dna binding region of receptor, binds to regulatory gene and activates transcription

Question 3

methotrexate treats this

Answer 3

arthritis, first line of defense against any immune disorder

Question 4

rare form of necrotizing vasculitis

Answer 4

wegeners granulomatosis

Question 5

males or females are more likely to get wegeners granulomatosis

Answer 5

men

Question 6

cyclophosphamide is a blank drug so it enzymatically activates a phosphoramide mustard which destroys dna

Answer 6

pro drug

Question 7

drug that must be taken with a lot of water due to bladder toxicity

Answer 7

cytoxan

Question 8

azathioprine is a blank that blocks blank synthesis

Answer 8

pro drug, purine

Question 9

treatment of unwanted immune responses that occur in autoimmune disease and transplant rejection

Answer 9

extrinsic regulation

Question 10

examples of antimetabolite agents

Answer 10

methotrexate azathioprine

Question 11

example of alkylating agents

Answer 11

cyclophosphamide

Question 12

prednisone is a blank

Answer 12

corticosteroid

Question 13

adverse effects of corticosteroids

Answer 13

fluid retention, diabetes, weight gain, bone mineral loss, thinning of skin

Question 14

cyclosporin A, rapamycin, fk506 are all derived from blank

Answer 14

fungal, bacterial

Question 15

new set of inhibitors for treating RA

Answer 15

JAK inhibitors

Question 16

cyclosporin A binds to blank and inhibits blank

Answer 16

cyclophilins, calcineurin

Question 17

tacrolimus binds to blank

Answer 17

fk binding proteins

Question 18

***inhibition of blank suppresses immune response by blocking activation step of interleukin synthesis

Answer 18

calcineurin

Question 19

cytotoxic drugs are toxic to blank which are the cells responsible for the autoimmune disorder

Answer 19

dividing lymphocytes

Question 20

one of the chemical messengers that helps regulates the inflammatory process

Answer 20

tumor necrosis factor

Question 21

tnf alpha induces

Answer 21

pro inflammatory cytokines and everything else that contributes to inflammation

Question 22

tnf alpha inhibitors treat blank but these are some side effects

Answer 22

ra, headache, rash, swelling, infections