Lec 11-2 - Pharm Manipulation Flashcards
methotrexate is specific for the blank phase of division
S
mechanism of action of steroids
lipid soluble compounds diffuse across cell membranes and bind cystolic receptors, dimer of heat shock protein displaced, exposing dna binding region of receptor, binds to regulatory gene and activates transcription
methotrexate treats this
arthritis, first line of defense against any immune disorder
rare form of necrotizing vasculitis
wegeners granulomatosis
males or females are more likely to get wegeners granulomatosis
men
cyclophosphamide is a blank drug so it enzymatically activates a phosphoramide mustard which destroys dna
pro drug
drug that must be taken with a lot of water due to bladder toxicity
cytoxan
azathioprine is a blank that blocks blank synthesis
pro drug, purine
treatment of unwanted immune responses that occur in autoimmune disease and transplant rejection
extrinsic regulation
examples of antimetabolite agents
methotrexate azathioprine
example of alkylating agents
cyclophosphamide
prednisone is a blank
corticosteroid
adverse effects of corticosteroids
fluid retention, diabetes, weight gain, bone mineral loss, thinning of skin
cyclosporin A, rapamycin, fk506 are all derived from blank
fungal, bacterial
new set of inhibitors for treating RA
JAK inhibitors
cyclosporin A binds to blank and inhibits blank
cyclophilins, calcineurin
tacrolimus binds to blank
fk binding proteins
***inhibition of blank suppresses immune response by blocking activation step of interleukin synthesis
calcineurin
cytotoxic drugs are toxic to blank which are the cells responsible for the autoimmune disorder
dividing lymphocytes
one of the chemical messengers that helps regulates the inflammatory process
tumor necrosis factor
tnf alpha induces
pro inflammatory cytokines and everything else that contributes to inflammation
tnf alpha inhibitors treat blank but these are some side effects
ra, headache, rash, swelling, infections
