Human Diseases L1: CVD1 Atherosclerosis & Risk factors Flashcards

1
Q

usually a combination of medication is required to reach a blood pressure below 140/90

how do calcium channel blockers work and give an example one

A

Calcium channel blockers reduce blood pressure by widening your blood vessels.

Common examples are amlodipine, felodipine and nifedipine. Other medicines, such as diltiazem and verapamil, are also available.

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2
Q

Atherosclerosis is a multi system disorder, because it affects different parts of the body.

where would atherosclerosis be present if it resulted in a: Aortic atheroma

A

Aorta

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3
Q

Atherosclerosis Pathogenesis

the accumulation of the fibrous tissue and lipids results in the formation of a ……………………?

A

Atheromatus/atherosclerotic plaque

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4
Q

a ………….. is a blood clot that forms in a vessel and remains there.

A

thrombus

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5
Q

Atherosclerosis is a multi system disorder, because it affects different parts of the body.

where would atherosclerosis be present if it resulted in a: Cerebral infarction

A

Brain

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6
Q

Atherosclerosis is a multi system disorder, because it affects different parts of the body.

where would atherosclerosis be present if it resulted in a: cerebral vascular disease

A

Brain

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7
Q

Atherosclerosis is a multi system disorder, because it affects different parts of the body.

where would atherosclerosis be present if it resulted in a: claudication

A

Arms/Legs (peripheral claudication)

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8
Q

what are the three non modifiable risk factors for atherosclerosis

A
  1. genetic predisposition
  2. increasing age
  3. sex (male>female)
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9
Q

Atherosclerosis is a multi system disorder, because it affects different parts of the body.

where would atherosclerosis be present if it resulted in a: renal vascular disease

A

Kidneys

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10
Q

the continual development of a atherosclerotic plaque, increases the shear stress at the site, resulting in a rupture.

the rupture has the potential to form what?

A

plaque rupture causes a thrombus to form over the plaque

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11
Q

a blood pressure of ? > 140/90 indicates what

A

high blood pressure

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12
Q

usually a combination of medication is required to reach a blood pressure below 140/90

how do Angiotensin II inhibitors work and give an example one

A

ARBs work in a similar way to ACE inhibitors. (relax blood vessels)

They’re often recommended if ACE inhibitors cause troublesome side effects

Common examples are candesartan, irbesartan, losartan, valsartan and olmesartan.

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13
Q

Atherosclerosis is a multi system disorder, because it affects different parts of the body.

where would atherosclerosis be present if it resulted in a: Myocardio infarction

A

Heart

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14
Q

Atherosclerosis is a multi system disorder, because it affects different parts of the body.

where would atherosclerosis be present if it resulted in a: gut ischemia

A

gut

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15
Q

blood pressure is stated as systolic/diastolic i.e 115/70

what does systolic and diastolic measure

A

systolic - heart pumping

diastolic - heart relaxing

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16
Q

what is the main CAUSE of vascular disease in the developed world

A

atherosclerosis

17
Q

usually a combination of medication is required to reach a blood pressure below 140/90

how do ACE inhibitors work and give an example one

A

Angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure by relaxing your blood vessels.

Common examples are enalapril, lisinopril, perindopril and ramipril.

18
Q

is a condition in which the blood flow (and thus oxygen) is restricted or reduced in a part of the body/tissue.

what condition is being described

A

Ischemia

19
Q

what is the target blood pressure reading for the over-80s

A

150/90 mmHg

20
Q

the formation of a thrombus can block an artery, which leads to symptoms of infarction

what is the difference between ischemia and infarction

A

Ischemia denotes diminished volume of perfusion, while infarction is the cellular response to lack of perfusion (tissue necrosis)

21
Q

what is the main pathological process causing cardiovascular disease

A

atherosclerosis

22
Q

Atherosclerosis Pathogenesis

atherosclerosis is initiated by the damage of what?

A

endothelial cells lining the blood vessels

23
Q

Atherosclerosis Pathogenesis

chronic inflamation results in the accumulation of ……………. and ………………… at the site of damage

A

lipids

fibrous tissue

24
Q

what are the 6 modifiable risk factors for atherosclerosis

A
  1. smoking
  2. high blood pressure

3 high cholesterol

  1. diabetes mellitus
  2. overweight/obesity
  3. harmful use of alcohol
25
Q
A
26
Q

which drugs help with high cholesterol

A

statins

27
Q

Atherosclerosis Pathogenesis

overtime the continued endothelial damage results in chronic ………….?

A

inflamation

28
Q

usually a combination of medication is required to reach a blood pressure below 140/90

how do Beta blockers work and give an example one

A

Beta blockers can reduce blood pressure by making your heart beat more slowly and with less force.

Common examples are atenolol and bisoprolol.

29
Q

Atherosclerosis is a multi system disorder, because it affects different parts of the body.

where would atherosclerosis be present if it resulted in a: ischemic heart disease

A

heart

30
Q

usually a combination of medication is required to reach a blood pressure below 140/90

how do Diuretics work and give an example one

A

Sometimes known as water pills, diuretics work by flushing excess water and salt from the body through your pee.

Common examples are indapamide and bendroflumethiazide.

31
Q

risk factors of atherosclerosis is broken down to two groups, what are they?

A

non modifiable and modifiable risk factors

32
Q

An ……………… is a clot that travels from the site where it formed to another location in the body.

A

embolism

33
Q

a systolic and diastolic reading of ……………… would cause a hypertension red flag warning

A

>160/100

34
Q

match the right drugs to their classes.

drugs

simvastatin

ramipril

atenolol

olmesartan

amlodipine

bendroflumethiazide

classes

angiotensin II Inhibitors

Beta Blockers

Calcium channel blockers

ACE inhibitors

Statins

Diuretics

A

simvastatin - Statins

ramipril - ACE inhibitors

atenolol - Beta Blockers

olmesartan - angiotensin II Inhibitors

amlodipine - Calcium channel blockers

bendroflumethiazide - Diuretics

35
Q
A