g.i tract - prof peters Flashcards

1
Q

carries food and liquid from the mouth to the stomach propelled by ……….?

A

peristalis

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2
Q

the upper and lower part of the oesophagus are bounded by what?

A

upper and lower oesophageal sphincters

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3
Q

the oesophagus is lined by what cell type

A

stratified squamous epithelium

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4
Q

the oesophagus musculature contains, striated and smooth.

what regions of the oesophagus would you find these

A

striated - upper thrid

smooth - remainder

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5
Q

what nerve innervates the oesophagus

A

vagus nerve CNX

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6
Q

what triggers the closure of the upper oesophageal sphincter

A

once food has entered the oesophagus

primary peristaltic wave (vagus nerve)

swallowing centre (pons and medulla)

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7
Q

what is the enteric nervous system

A

its the nervous sytsem that governs the GI system

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8
Q

what do the circular fibres do behind bolus during peristalsis

A

contract to squeeze it down to stomach

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9
Q

what do longitudinal fibres infront of bolus do, during peristalsis

A

contract to shorten distance to travel

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10
Q

after swallowing how many seconds later does the lower oesophageal sphincter open

A

2-3 seconds

prevents reflux

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11
Q

when would a secondary peristaltic wave occur

A

when sticky food becomes lodged in the oesophagus

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12
Q

what digest protein in the stomach

A

pepsin and HCl

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13
Q

approximatley how much gastric juices is produced by the gastric glands

A

2 litre/day

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14
Q

mechanical activity occurs as two types. what are they

A

orad stomach

caudad stomach

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15
Q

for storage of ingested material in the stomach. must stomach relax or contract

A

relax via vagus nerve

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16
Q

would you expect to find greater wave activity in the orad or the caudad region

A

caudad region

17
Q

where would you find thick musculature in the stomach

orad region or caudad region

A

caudad region

18
Q

why is there minimal mixing of contents for long periods in the orad region

A

allows for carbohydrate partial digestion by salivary glands

19
Q

what occurs during retropulsion

A

mixing of gastric contents, whilst reducing chyme to small particles, so that it passes through the pylorus

20
Q

Strength of antral wave determines escape of chyme through pyloric sphincter

which is goverened by what

A

gastric factors

duodenal factors

21
Q

what are the gastric factors that affect emptying of chyme

A

stretch of smooth muscle

stimulation of intrinsic nerve plexuses

increased vagus nerve activity and gastrin release

consistency of chyme

22
Q

what stimuli in the duodenum affects gastric emptying

A

fat - duodenum needs to prepare

acid - pancrease needs to prepare

hypertoncity - osmotically active

distension

23
Q

what is the gastric mucosa composed of

A

lining of stomach

pits, invaginations of the surface

glands, at the base of the pits

24
Q

in which region of the stomach would you find an increase in parietal and chief cells.

oxyntic or plyoric

A

oxyntic area

25
which regions would you find d cells pyloric or oxyntic
pyloric
26
functions of gastric secretions HCl
activates pepsiongen to pepsin denatures protein kills most microorganisms
27
functions of gastric secretions pepsinogen
inactive precursor of the peptidase
28
functions of gastric secretions histamine
stimulates HCl secretion
29
functions of gastric secretions Mucus
protective | (pyloric gland area and antrum)
30
functions of gastric secretions gastrin
stimulates HCl secretion
31
functions of gastric secretions somatostatin
inhibits HCl secretion
32
what are the three phases of gastric acid secretion
cephalic phase - in the head gastric phase - when food is in stomach intestinal phase - after food has left stomach
33
what are the three inhibition stages of gastric acid secretion
cephalic phase - vagal nerve activity decreases gastric phase - ph falls as food exits stomach intestinal phase - factors that reduce gastric motility, reduce gastric secretion
34
Drugs that reduce gastric acid secretion are used in the treatment of...
peptic ulcer gastro-oesophageal reflux disease acid hypersecretion
35
what drug acts as a proton pump inhibitor
omeprazole
36
what conditions need to be met for the success of omeprazole
timing of dosing orally once daily full effect achieved after repeated dosing
37