Blood 9

Question 1

What is needed to make Fibrin stable?

Answer 1

Factor 13 and calcium

Question 2

What makes up the network of a blood clot?

Answer 2

Fibrin

Question 3

What is Fibrin derived from?

Answer 3

Fibrinogen in the presence of Thrombin

Question 4

What is the Precursor to Thrombin?

Answer 4

Prothrombin in the presence of Prothrombinase

Question 5

What is unique about Prothrombinase?

Answer 5

It is not a single substance but a complex substance made out of several things

Question 6

What is Prothrombinase made of?

Answer 6

• Factor X
• Factor V
• Calcium ions
• Phospholipids on the platelet surface

Question 7

Which parts of prothrombinase are present in an active form?

Answer 7

Factors V and X

Question 8

How many pathways lead to an active factor X?

Answer 8

Two

Question 9

What are the names of the two pathways that lead to an active factor X?

Answer 9

Intrinsic and Extrinsic pathway

Question 10

What is clotting initiated by when you put blood in a test tube?

Answer 10

The glass of the test tube because it is a foreign substance

Question 11

What pathway of blood clotting is activated by blood meeting the foreign substance of glass in at es tube?

Answer 11

The intrinsic pathway

Question 12

What is meant by the Intrinsic blood clotting pathway?

Answer 12

Everything needed for the blood to clot is already present in the blood and you don’t need to add anything

Question 13

What does the Intrinsic Pathway begin with?

Answer 13

Activation of factor XII through contact activation

Question 14

What is factor XII activated by in the Intrinsic pathway?

Answer 14

Contact activation

Question 15

What does factor XII activate in the Intrinsic Pathway?

Answer 15

Factor XI

Question 16

What activates factor XI in the intrinsic pathway?

Answer 16

Factor XII

Question 17

What does factor XI activate and what does it need to be in the presence of in the intrinsic pathway?

Answer 17

Factor IX in the presence of calcium

Question 18

What activates factor IX in the intrinsic pathway?

Answer 18

Factor XI in the presence of calcium

Question 19

What occurs in the intrinsic pathway after factor IX has been activated?

Answer 19

It forms a complex with VIII, calcium and phospholipids from platelets

Question 20

What is Tenase?

Answer 20

The complex of Factor IX, VIII, calcium and phospholipids from platelets that forms in the intrinsic pathway

Question 21

What does Tenase do in the Intrinsic pathway?

Answer 21

It activates factor X

Question 22

When does the Extrinsic pathway of blood vessels occur?

Answer 22

When tissues are damaged inside the living body

Question 23

What triggers clot formation in the Extrinsic pathway of blood clotting?

Answer 23

TF becoming exposed when a tissue is damaged

Question 24

What does TF form a complex with in the Extrinsic pathway?

Answer 24

Factor VII, Calcium and the phospholipids from platelets

Question 25

What happens after TF forms its complex in the extrinsic pathway?

Answer 25

It activates factor X

Question 26

What does the activated factor X do in the common pathway?

Answer 26

Forms a complex called prothrombinase

Question 27

What does the Extrinsic pathway require the addition of?

Answer 27

TF which is not usually found in the blood

Question 28

Which factor deficiencies cause severe bleeding?

Answer 28

VII, VIII

Question 29

Which clotting factor causes moderate bleeding?

Answer 29

XI

Question 30

What does the lack of clotting factor XII cause?

Answer 30

No bleeding problem in vivo; failure to clot in vitro