Blood 10 Flashcards
What is Thrombin produced by and what does it need to be in the presence of in the common pathway?
The inactive precursor prothrombin in the presence of prothrombinase complex
What does Thrombin activate in the common pathway?
Fibrinogen to fibrin
What is needed to convert Fibrin to its stable form?
Calcium and factor XIII
What two pathways can the active factor X pathway come from in vivo?
The Initiation of clotting pathway and the Amplification of plotting pathway
What are the steps in the Initiation pathway in vivo?
Tissues damage releases TF and in the presence of VII and calcium and phospholipid from the platelet surface activates factor X in the common pathway
What is different about the Initiation pathway in Vivo?
The combination produced activated both factor X in the common pathway and factor IX in the Amplification pathway
What is factor IX used?
In the amplification pathway in vivo
What is factor IX a component in and in what pathway?
Tenase in the amplification pathway
What can the combination produced in the initiation pathway activate?
Factor X and factor IX
What occurs when factor IX is activated by the initiation pathway?
It becomes part of Tenase in the amplification pathway
Which factor is not present in the Amplification pathway In Vivo and why?
Hageman’s factor XII, because it only causes problems clotting In Vitro
What starts off the Amplification pathway In Vivo?
Activation of factor IX
When can factor IX be produced in the amplification pathway In Vivo?
It can be produced by Initiation pathway or by factor XI in the presence of calcium
How is factor IX activated in the Amplification pathway in Vivo?
It is activated by factor XI in the presence of calcium
Once factor IX is activated in the Amplification pathway in vivo what occurs?
It joins the tenase complex and activates factor X in the common pathway
What activates factor XIII in the common pathway in vivo?
Thrombin
What can Thrombin activate in the Prothrombinase complex in vivo?
Factor V
What does Thrombin activating factor V in the prothrombinase complex in the common pathway do in vivo?
It causes the Prothrombinase complex to act more effectively