Week 1 Drugs Flashcards
Local Anesthetics
Action:block voltage gated sodium channels,prevent action potentials
Use:Pain management
ION CHANNELS
Benzodiazepines
Action:Bind to GABAa receptor(CL channel) enhances GABA, hyperpolarization
Use:Pain, Psych
ION CHANNELS
Albuterol
Action:B2 agonist
Use:Asthma
CAMP RECEPTORS
Propranolol
Action:B2 antagonist
Use:Hypertension
CAMP RECEPTORS
Bethanechol
Action:muscarinic agonist
Use:Atonic bladder
IP3 DAG RECEPTOR
Ipratropium
Action:muscarinic antagonist
Use:Asthma
IP3 DAG RECEPTOR
Imatinib
Action:tyrosine kinase inhibitor
Use:Leukemia
Statins
Action:inhibitors of HMG-CoA reductase(down cholesterol) ,upreg. Of LDL receptors on hepatocytes
Use:High LDL
Nuclear Receptors
SSRI
Action:Block serotonin reuptake
Use:Depression
TRANSPORTER
Vinca alkaloids
Action:prevent polymerization of tubulin to microtubules, cells arrested in metaphase
Use:Cancer
STRUCTURAL PROTEIN
Antacids
Action:neutralize gastric acid
Use:GERD
Mesna
Action:reacts in the bladder with Acrolein(product of cyclophosphamide an anticancer drug)
Use:Hemorrhagic cystitis
NON RECEPTOR MEDIATED
Cholestyramine,Colestipol,Colesevelam
Action:bind to bile acids in the intestinal lumen prevent reabsorption
Use:hyperlipidemia
NON RECEPTOR MEDIATED
Dimercaprol
Action:chelates heavy metals
Use:Mercury, Arsenic,lead poisoning
Pyrimidine and purine analogs
Action:incorporated into nucleic acids to alter their function
Use:Cancer
Phenoxybenzamine
Action:irreversible a-adrenoceptor blocker
Use:pheochromocytoma
Aspirin and omeprazole
Action:irreversible enzyme inhibitor
Use:
Ketamine
Action:Noncompetitive antagonist of NMDA receptors
Use:IV anesthetic, Pain
Protamine
Action:positively charged protein counteracts negative charged anticoagulant, heparin
Use:
Famotidine
Action:Inverse Agonist
Use:
Metoprolol
Action:Inverse Agonist
Use:
Amphetamine
Action:releases noepi. From nerve terminals
Use:
Mannitol
Action:increases the osmolarity of various body fluids, promotes diuresis
Use:Cerebral edema
NON RECEPTOR MEDIATED
