44. Uterus Path

Question 1

A 55 year old postmenopausal women comes to her doctor with complaints of vaginal bleeding.Ultrasound is done notable for a endometrial mass. A biopsy in taken and the doctor notes that the histology resembles a phyllodes tumor in the breast. What is this growth related to?

A. KRAS mutation
B.  BRCA1 Mutation 
C. JAZF1 mutation 
D. HER2/neu
E.BCR-ABL

RFA

Answer 1

Ans. C JAZF1 mutation is correlated to tumors of the uterus endometrium

A. KRAS mutation- Adenomatous polys, colorectal cancer, Adenocarcinoma of the lungs, Pancreatic cancer

B. BRCA1 Mutation- Breast ovarian and pancreatic cancer

D. HER2/neu- Breast and gastric carcinomas

E.BCR-ABL- CML and ALL

Question 2

A 55 year old nulliparous woman presents with abdominal pain. Years ago, she had undergone biopsy of the endometrium which showed complex hyperplasia with atypia. Her new symptom likely stems from what type of neoplasm? (MG)

A. Type I Endometrial Carcinoma
B. Type II Endometrial Carcinoma
C. Malignant Mixed Mullerian Tumor
D. Clear cell carcinoma
E. Serous Carcinoma of the uterus

Answer 2

A. Type I Endometrial Carcinoma

nulliparous is a trigger word for this

complex hyperplasia with atypia is the precursor lesion

Question 3

A 45 year old post-menopausal woman has began experiencing spotting. One year ago, she was on tamoxifen to treat a breast carcinoma which is now in remission. Her current condition is likely due to increased levels of…. (MG)

A. Progesterone
B. LH
C. Estrogen
D. FSH
E. DA

Answer 3

C. Estrogen

Dx is endometrial polyp… a common complication of tamoxifen use