15. RTI-5 Flashcards
A 2 year old girl is brought to the pediatricians by her parents because of a persistent “barking cough”. Imaging is done showing a noticeable “steeple sign”. What is the viral protein that helps evade the immune system in this infections?
A.M B.L C. HN D. F E. P/F
RFA
Ans- E. P/F-helps in the evasion of immune response by inhibiting interferon-alpha/beta signaling pathway.
A. M- Structal protein
B. L-Multifunctional Polymerase
C. HN- Structural hemagglutinin and neuraminidase
D. F- fusion protein role in syncytium formation
A microbiologist is study the bacteria that causes whooping cough. He is attempting to deactivate the virulence factor that causes localized tissue damage. What should the microbiologist target?
A. Pertussis toxin B. FHA C.Dermonecrotic cytotoxin D. Fimbria E. Pertactin
RFA
ANS. C Whooping cough is caused by Bordetella pertussis Dermonecrotic toxin along with Tracheal cytotoxin are responsible for local tissue injury
A. Pertussis toxin- Systemic toxicity
B, D, E- FHA, Fimbria, Pertactin- all are bacterial attachment protein for Bordetella pertussis
A 3 y/o girl from rural China is adopted and brought to the US. She develops a “barking” cough with a large amount of sputum and has a fever 101.4F. A sputum sample is cultured and should be plated on what type of media?
A. Chocolate agar B. Chocolate agar + NAD + Hemin C. Tellurite D. Bordet-Gengou + charcoal agar E. Tinsdale agar
SZ
Ans. D. Bordet-Gengou + charcoal agar is specific for Bordetella pertussis
Chocolate agar + NAD + Hemin = H. Influenza
Tellurite and Tinsdale = C. diphtheriae
A 2 month old boy with Downs Syndrome diagnosed with a enveloped, helical, (-)ssRNA virus that replicates in the nasopharyngeal epithelium. Which of the following determines outcome of the patient?
A. Immune response B. Anatomy of airway C. Virus Replication Ability D. Tropism for respiratory epithelium E. Fusion factor protein
SZ
Ans. A, B, D
Immune response, Anatomy of airway, Tropism for respiratory epithelium
The patient has RSV.
