6. Acute Inflammation Flashcards
A patient is found to have a reduced inflammatory response. It is found that he lacks cyclooxygenase. Which of the listed inflammatory mediators will be found in low supply?
A. IL-1 B. TXA2 C. LTA D. LXA A E .LTC
RFA
Ans.B TXA2 , PGI2, PGE2 are the products of cyclooxygenase (prostaglandins)
A. IL-1 should not be affected
C, D E are all Leukotrienes and are are a product of 5-Lipoxygenase
NOTE:Lipoxygenase and Cyclooxygenase use Aradonic acid to make their products
Which of the following inflammation mechanism is associated with Pulmonary capillaries?
A. Transcytosis
B. Endothelial contraction
C. Leukocyte-dependent
D. Direct Injury
RFA
Ans.C Leukocyte-dependent-
- Mostly in venule
- Pulmonary capillaries
- Late Response
- Long Lived
A. Transcytosis:
- Venules
- Vascular endothelium-derived growth factor
B. Endothelial contraction:
- Venule
- Vasoactive mediators( histamine, leukotrienes )
- Most common
- Fast and short lived (minutes)
D. Direct Injury:
- Arterioles capillaries and venules
- Toxins, burns, chemicals
- Fast and Long lived (Hours to days)
A 22 year old female presents to the clinic with a red, swollen foot. The skin is hot to the touch, and she complains of pain. The plasma derived mediators of the acute inflammation she is experiencing are mainly produced where? (MG)
A. Brain B. Spleen C. Thymus D. Liver E. Blood F. At the site of inflammation
D. Liver
A 22 year old female presents to the clinic with a red, swollen foot. The skin is hot to the touch, and she complains of pain. If you were to take a histological sample of the inflamed tissue in her foot and saw WBC’s clinging to the endothelial surface (periphery) of a blood vessel, you would be looking at what stage of leukocyte recruitment? (MG)
A. Margination
B. Rolling
C. Adhesion
D. Chemotaxis
A. Margination
When blood flow slows early in inflammation, the wall shear stress decreases and more WBC’s assume a peripheral position along the endothelial surface.
