Pharm Week 2 Flashcards
1
Q
Cyclophoshamide
A
Action:bioactivated by metabolism to become active
Treatment for:Cancer
2
Q
Phenobarbital
A
Action:increases syth of P450 isoforms
Treatment for:
3
Q
Rifampin
A
Action:increases syth of P450 isoforms
4
Q
Carbmazpine
A
Action:increases syth of P450 isoforms
5
Q
St Johns Wort
A
induces CYP3A4 (lowers indinavir(HIV) med concentration )
6
Q
Amiodarone
A
inhibits P450
7
Q
Cimetidine
A
inhibits P450
8
Q
Ketoconazole
A
inhibits P450
9
Q
Erthromycin
A
inhibits P450
10
Q
Chloramphenicol
A
inhibits P450
11
Q
Grapefruit Juice
A
inhibits P450 and P-glycoprotien
12
Q
Macrolide Antiboitics
A
inhibits P-glycoprotein, causes increase serum levels of drugs such as digoxin
13
Q
Acetaminophen
A
ingested by liver for safe excretion toxic at high doses
14
Q
N-actlcysteine
A
Supplies cysteine for glutathione production
15
Q
Tabaco Smoke
A
induces P450
