28. Antihyperlipidemic Drugs Flashcards
A 48 year old patient is on the drug Lovastatin and it has effectively reduced his LDL level. His physician wants to lower his TG more what would be the best choice for combo therapy?
A. Niacin B.Fenofibrate C. Colestipol D. Ezetimibe E. Gemfibrozil
RFA
Ans. B- doesn’t increase statin metabolism so less likely to increase risk of rhabdomyolysis while also decreasing TG the most
A: Niacin- greatly increases HDL and lowers LDL but also has a lot of AE and not DOC for lowering TG
C. Colestipol- lowers LDL but increases TG
D. Ezetimibe- is used with statins to reach LDL goal
E. Gemfibrozil- lowers TG but also increases metabolism of Statins increasing the chances rhamdomylis
A patients is found after testing to have very high LDL levels and his physicians want to aggressively lower the LDL levels. Which drug would be the best choice to achieve this goal?
A. Fluvastatin B. Simvastatin C. Rosuvastatin D. Atorvastatin E. Pravastatin
RFA
Ans. C Rosuvastatin in the most potent Statin drug so it will have the greatest effect
The statin power rankings are
Rosuvastatin Atorvastatin Simvastatin Lovastatin Pravastatin Fluvastatin
A 45 year old male has a history of hyperlipidemia. He has elevated serum LDL and TGs and is currently on a statin. You want to add a fibrate for combination fibrate. Which drug do you choose to minimize the risk of rhabdomyolysis? (MG)
A. Gemfibrozil B. Fenofibrate C. Bezafibrate D. Niacin E. Colestipol F. Colesevelam
B. Fenofibrate
This fibrate does not inhibit statin metabolism annd is much less likely to increase the risk of rhabdomyolysis.
A 55 year old woman has a history of hyperlipidemia. Her serum TGs levels are 500mg/dL. Which value might be inaccurate due to her TG value? (MG)
A. HDL
B. LDL
C. VLDL
D. Chylomicrons
B. LDL
LDL values are usually calculated and are only accurate when TGs are <400mg/dl and patients are fasting. This means patients with Type IV or V hypertriglyceridemia may have inaccurate LDL values.
