7. Pharmacodynamics II

Question 1

Which drug fits the action shown by the red line?

A. Famotidine

B. Albuterol

C.Ketamine

D. Protamine

E. Bethanechol

RFA

Answer 1

Ans A. Famotidine- The red shows the action of an inverse agonist, it reverses the effect of the receptor. Famotidine is used to treat stomach ulcers a lot of inverse agonist are antiacids.

B. Albuterol- is a B2 agonist used for asthma( blue line)

C. Ketamine-is an IV anesthetic that acts as a noncompetive antagonist on NDMA receptors (Black Line)

D. Protamine- is a chemical antagonist, it is a postively charged substance that neutrulizes negativley charged herapin( Black line)

E. Bethanechol- is a muscharinic agonist used for atonic bladder( blue line)

Question 2

From the image what can you infer about the drug?

A. The drug is not selective

B. Receptor Y has more efficacy of the drug
C. Receptor Y has less efficacy of the drug

D. The TI of the drug is 5

E. The drug is selective

RFA

Answer 2

Ans. A The drug is not selective- For a drug to be consider selective it needs to have a 10 fold preferance for its first receptor over its second.

B & C - X and Y have equal efficacy of the drug

D. Can’t calculate TI for the drug to do that need TI= TD/ ED or TI=LD/ED

E. Not 10 fold differense so NO