9. Nephritic Disorders Flashcards
In general, when viewing renal biopsy specimens under microscopy, you will see a granular IF when there are deposits of what? (MG)
A. Antibodies B. Complexes C. p-ANCA D. c-ANCA E. Collagen F. Amyloid
B. Complexes
Granular IF seen in disorders where there are antigen-antibody complexes
Linear IF seen in Goodpasture syndrome with antibody deposits
An 16 year old boy presents to his primary care physician after noticing blood in his urine. Mild sensorineural hearing loss and vision problems were diagnosed when he started school. Investigations reveal hematuria and heavy proteinuria. A renal biopsy is taken and examined under EM to reveal basement membrane splitting with thickened and thinned portions of the GBM as well as macula densa lamination. The defects in the basement membrane are due to mutations in which two genes?
A. COL1A1 & COL1A2 B. RET & MYC C. COL4A4 & COL4A5 D. E6 & E7 E. NF1 & NF2
C. COL4A4 & COL4A5
Alport Syndrome
A 40 year old man visits his physician complaining of blood while he pees. He complement level is measured and it is low. Which Nephritic disorder may the man have?
A. IgA Nephropathy B. SLE class II C. SLE Class V D.Alport's Syndrome E. Membranoproliferative Glomerulonephritis
RFA
ANS. E Membranoproliferative Glomerulonephritis- is the only one listed that has Low complement low, all the over are normal
SLE- class I, II and V are normal III and IV.
A 68 year old man comes to his doctor he has severe hematuria and proteinuria .Lab test show he is has low complement with high anti- DNA levels, EM show crescents and necrotizing lesions, what does this patient have?
A.Class IV SLE Nephritis B. IgA Nephropathy C. Class II SLE Nephritis D. Post -Streptococcal GN E. Membranoproliferative Glomerulonephritis
RFA
ANS. A Class IV SLE Nephritis. The high anti-DNA points in you the direction SLE and and the low complement makes it Class IV instead of Class II
A 30 y/o Hep B male present with hematuria and edema. He has subendothelial deposits on EM. H&E with silver stain can be described as which of the following?
A. Subendothelial Humps
B. Tram-track splitting of the basement membrane
C. Hyperproliferation and Crescents
D. Segmented Areas with Increase in Mesengial Matrix
SZ
Ans B. Tram-track splitting of the basement membrane
A 4 y/o child presents to the ED with hematuria, slight proteinuria, and RBC and granular casts in his urine. His mother states he has just been diagnosed with Celiac Disease. He has had a purpura like rash for 4 days. Which of the following disease might the child be diagnosed?
A. PSGN B. MPGN C. RPGN D. Berger's Disease E. Lupus nephritis
SZ
Ans D. Berger’s Disease
