24. Path of Neoplasia IV

Question 1

A 65 y/o male leather worker presents to an oncologist for follow-up appointment. His cancer is linked to his long term exposure to azodyes. Which of the following cancers might he have?

A. Lung CA
B. Leukemia
C. Gastric CA
D. Hepatocellular CA
E. Meothelioma

SZ

Answer 1

Ans. D Hepatocellular CA
Azodyes and aromatic amines can lead to hepatocellular CA and bladder CA

A. Lung CA is caused by asbestos or polycyclic aromatic hydrocarbons
B. Leukemia caused by direct acting alkylating agents, cyclophosphamide
C. Gastric CA- Nitroamines and amides
E. Mesothelioma- Asbestos

Question 2

Which of the following mutations could lead to Mantle cell lymphoma development?

A. CCND1
B. CMYC
C. NMYC
D. ABL
E. KRAS

SZ

Answer 2

Ans. A CCND1
Cyclin and cyclin dependent kinase mutation dysregulates the cell cycle and leads to Mantle cell lymphoma (t (11;14))

B. CMYC- Burkitt’s lymphoma
C. NMYC- Neuroblastoma
D. ABL- CML
E. KRAS- colon CA

Question 3

A 39 year old woman comes is diagnosed with HBV, which cancer does this patient now have an increased risk of developing?

A. Burkitt's Lymphoma 
B. Papilloma
C. Hepatocellular carcinoma
D. Nasopharyngeal Carcinoma
E. Cervical Cancer

RFA

Answer 3

Ans. C. Hepatocellular carcinoma is associated with Hepatitis B Virus

A. & D- Burkitt’s Lymphoma & Nasopharyngeal Carcinoma- Epstein-Barr Virus

B&E Papilloma & Cervical Cancer- HPV

Question 4

A 42 year old mans comes to the doctor with purple colored skin after testing the man is diagnosed with Kaposi Sarcoma. Which infection may this man may have contracted?

A. HTLV 
B.HHV-8
C.HBV
D.  H. Pylori 
E. EBV

RFA

Answer 4

Ans. B HHV-8 can cause Kaposi sarcoma.

A. HTLV- Human T cell leukemia/ lymphoma

C. HBV- Hepatocellular CA

D. H. Pylori- B cell lymphoma

E. EBV- Burkitt’s lymphoma/ nasopharyngeal CA