Anemia Drugs Flashcards
Ferrous sulfate
Oral iron therapy
Ferrous Gluconate
Oral iron therapy
Ferrous Fumarate
Oral iron therapy
Ascorbic Acid
Administered with Oral iron therapy for optimal absorption
Iron Dextran
Parenteral iron given to hemodialysis patients
Highest risk of type I hypersensitivity reaction
Sodium ferric gluconate complex
Parenteral iron given to hemodialysis patients
Iron sucrose
Parenteral iron given to hemodialysis patients
Adverse Iron Therapy
Black stool and other GI issues
Metabolic Acidosis
Organ toxicity leading to coma or death
Deferoxamine
Given IV binds to systemic iron
Promotes iron excretion in urine and feces
Indicated in moderate to severe iron toxicity
Deferasirox
Oral preparation
Only effective in reducing iron absorption if given within one hour of iron ingestion
Given outpatient for chronic iron toxicity treatment
Metformin
Alter gut microflora
Inhibits absorption of B12
Neomycin
Alter gut microflora
Inhibits absorption of B12
Nitrous oxide anesthesia
Converts cobalamin(I) to to inactive cobalamin(III)
Inhibits b12 absorption
Proton pump inhibitors
increases gastric PH
Inhibits b12 absorption
Histamine 2 receptor antagonist
increases gastric PH
Inhibits b12 absorption
Hydroxocobalamin
Preferred B12 therapy
Highly protein bound form which remains in circulation for a longer time
Cyanocobalamin
Vit. B12 Therapy
Trimethoprim
Inhibits DHF reductase
Causing Folate deficiency
Primimethatmine
Inhibits DHF reductase
Causing Folate deficiency
Methotrexate
Inhibits DHF reductase
Causing Folate deficiency
Phenytoin
reduces serum folate.
Mechanism unknown
Filgrastim
Stim JAK/STAT receptors
Increase production and function of neutrophils
Given parenterally to patient with chemo induced neutropenia or bone marrow suppression
Is better tolerated than sargramostim
Sargramostim
Stim JAK/STAT receptors
Increase production and function of neutrophils
Stimulates all myeloid lines
Given parenterally to patient with chemo induced neutropenia or bone marrow suppression
Interleukin 11
Acts via cell surface cytokine receptor
Stimulates growth of primitive megakaryocytic progenitors
Increases platelets and neutrophils
Reduces need for platelet transfusion.
Hydroxurea
Increases Hbf
Decreases expression of Neutrophils adhesion molecules
Increases endothelial production vasodilatory NO
Used in treatment of SCD
