Anemia Drugs

Question 1

Ferrous sulfate

Answer 1

Oral iron therapy

Question 2

Ferrous Gluconate

Answer 2

Oral iron therapy

Question 3

Ferrous Fumarate

Answer 3

Oral iron therapy

Question 4

Ascorbic Acid

Answer 4

Administered with Oral iron therapy for optimal absorption

Question 5

Iron Dextran

Answer 5

Parenteral iron given to hemodialysis patients

Highest risk of type I hypersensitivity reaction

Question 6

Sodium ferric gluconate complex

Answer 6

Parenteral iron given to hemodialysis patients

Question 7

Iron sucrose

Answer 7

Parenteral iron given to hemodialysis patients

Question 8

Adverse Iron Therapy

Answer 8

Black stool and other GI issues

Metabolic Acidosis

Organ toxicity leading to coma or death

Question 9

Deferoxamine

Answer 9

Given IV binds to systemic iron
Promotes iron excretion in urine and feces
Indicated in moderate to severe iron toxicity

Question 10

Deferasirox

Answer 10

Oral preparation
Only effective in reducing iron absorption if given within one hour of iron ingestion

Given outpatient for chronic iron toxicity treatment

Question 11

Metformin

Answer 11

Alter gut microflora

Inhibits absorption of B12

Question 12

Neomycin

Answer 12

Alter gut microflora

Inhibits absorption of B12

Question 13

Nitrous oxide anesthesia

Answer 13

Converts cobalamin(I) to to inactive cobalamin(III)

Inhibits b12 absorption

Question 14

Proton pump inhibitors

Answer 14

increases gastric PH

Inhibits b12 absorption

Question 15

Histamine 2 receptor antagonist

Answer 15

increases gastric PH

Inhibits b12 absorption

Question 16

Hydroxocobalamin

Answer 16

Preferred B12 therapy

Highly protein bound form which remains in circulation for a longer time

Question 17

Cyanocobalamin

Answer 17

Vit. B12 Therapy

Question 18

Trimethoprim

Answer 18

Inhibits DHF reductase

Causing Folate deficiency

Question 19

Primimethatmine

Answer 19

Inhibits DHF reductase

Causing Folate deficiency

Question 20

Methotrexate

Answer 20

Inhibits DHF reductase

Causing Folate deficiency

Question 21

Phenytoin

Answer 21

reduces serum folate.

Mechanism unknown

Question 22

Filgrastim

Answer 22

Stim JAK/STAT receptors

Increase production and function of neutrophils

Given parenterally to patient with chemo induced neutropenia or bone marrow suppression

Is better tolerated than sargramostim

Question 23

Sargramostim

Answer 23

Stim JAK/STAT receptors

Increase production and function of neutrophils

Stimulates all myeloid lines

Given parenterally to patient with chemo induced neutropenia or bone marrow suppression

Question 24

Interleukin 11

Answer 24

Acts via cell surface cytokine receptor

Stimulates growth of primitive megakaryocytic progenitors

Increases platelets and neutrophils

Reduces need for platelet transfusion.

Question 25

Hydroxurea

Answer 25

Increases Hbf

Decreases expression of Neutrophils adhesion molecules

Increases endothelial production vasodilatory NO

Used in treatment of SCD