12. Tissue Repair: Regeneration

Question 1

A 65 year old female presents to the clinic with proteinuria and bilaterally palpable kidneys. A renal biopsy yields waxy, pale tissue that polarizes apple green under EM. The cellular compartment where the misfolded protein responsible for her condition is deposited contains all of the following adhesive molecules except for… (MG)

A. Laminin
B. Fibronectin
C. Desmosomes
D. Integrins
E. ICAMs

Answer 1

E. ICAMs

ICAM stands for intracellular cell adhesion molecule. All other choices are found in the extracellular matrix.

The patient has amyloidosis in her kidneys, and amyloids deposit in the extracellular space.

Question 2

A histologist is looking at a slide that is characterized by non-rigid tertiary structure.

A. Laminin
B.Elastin
C. Collagen
D. Hydrated Gels
E. Fibronectin 

RFA

Answer 2

Ans. B. Elastin-non rigid tertiary structure which provides tissues with elastic recoil

A. Lammin- A adhesive molecule

C. Collagen- most abundant protein in the body, provides mechanical support

D. Hydrated Gels- Glycosaminoglycans and proteoglycans, negatively charged, give organs turgor and store growth factors

E. Fibronectin- Adhesive molecule

Question 3

A man with keloids is found to have a genetic issue with over activation of a growth factor which is most likely?

A. INF-G 
B.FEGF
C.TNF-A
D. TGF-B
E. IL-10

RFA

Answer 3

Ans. D. TGB-B is the growth factor most associated with collagen deposition which over activation can cause Keloids

A. INF-G- is involved with Neutrophil activation

B. FEGF is important in angiogenesis

C. TNF-A- is important in acute inflammation

E. IL-10 is important in antiinflammatory

Question 4

If you patient has an eye injury that has damaged the tissue, what type of drug would you treat with? (and be able to explain why) (MG)

A. NAIDs
B. Steroids
C. Tyrosine kinase agonists
D. PKA stimulatory drugs (Gs)

Answer 4

B. Steroids

You use steroids for eye injuries to prevent fibrous tissue from forming there