10. Adrenergic Agonists & Antagonists II Flashcards
A 55 year old man visits his PCP after recurrent episodes during which his heart races, his palms sweat, and he feels anxious. Imaging studies reveal presence of pheochromocytoma. Which drug that treats this condition binds irreversibly? (MG)
A. Phentolamine
B. Parzosin
C. Phenoxybenzamine
D. Mirtazapine
C. Phenoxybenzamine
Phentolamine also treats pheochromocytoma but binds reversibly.
A 55 year old man presents to his PCP with complaints of difficulty voiding urine. he also has a 10 year history of hypertension. DRE reveals an enlarged prostate. What should the PCP prescribe to alleviate both the patient’s urinary symptoms and hypertension? (MG)
A. Tamsulosin
B. Phentolamine
C. Prasosin
D. Mirtazapine
C. Prasosin
Can’t prescribe tamsulosin if they have HTN bc it barely effects BP
A patient is given a drug that works as an irreversible non selective alpha antagonist before their surgical removal of a tumor. Which medication is the patient given?
A. Prazosin B. Atenolol C. Phentolamine D. Labetalol E.Phenoxybenzamine
RFA
ANS. E- Phenoxybenzamine- is a irreversible non selective alpha antagonist, given before surgical removal of tumors
A- Prazosin- is a selective alpha 1 DOC for BPH
B. Atenolol- is a B1 selective blocker selective used for patient that have HTN with pulmonary issues
C. Phentolamine- is a reversible- non selective alpha antagonist and is used in Hypertensive crisis due to stimulant drug test and diagnosis of pheochromocytoma
D. Labetalol- is a competitive antagonist of B1 and A1 receptors is more potent for B and is used for hypertension treatment and is safe for pregnant women.
A 42 year old women is undergoing preoperative preparation for resection of pheochromocytoma. Which medication should she be given.
A. Phentolamine B. Terazosin C. a-Methyltyrosine D. Reserpine E.Labetalol
RFA
Ans. C. a-methyltyrosine- is a competitive inhibitor of tyrosine hydroxylase it is used for the management of malignant pheochromocytoma and preoperative prep.
A. Phentolamine- is used in diagnosis of pheochromocytoma
B. Terazosin- is an alpha 1 inhibitor used in HTN and BPH
D. Risperidone- irreversible blocks VMAT, causing vesicles to not store NE or dopamine , was used in the past to treat hypertension
E. Labetalol- is a competitive antagonist of B1 and A1 receptors is more potent for B and is used for hypertension treatment and is safe for pregnant women
Tetrabenazine is given to your patient with Huntington’s chorea. Which of the following is the MOA for this drug?
A. Irreversible inhibitor of VMAT B. Reversible inhibitor of VMAT C. Antimuscarinic antagonist D. Block MAO reuptake E. Muscarinic agonist
SZ
Ans. B. Reversible inhibitor of VMAT
The pupillary constrictor muscle contracts to cause miosis by stimulation of which receptor?
A. Alpha 1 B. Beta 2 C. M3 D. Alpha 2 E. Beta 1 F. M2
SZ
Ans. C. M3
