12. Autacoids & Autacoid Antagonists

Question 1

A patient has seasonal allergies but works as construction worker and doesn’t want to have any drowsy side effects since she works with heavy machinery on a regular basis. Which medication would you recommend for the patient

A. Cetirizine
B.Promethazine
C. Cyclizine 
D. Chlorpheniramine 
E. Meclizine 

RFA

Answer 1

ANS. A Cetirizine is the only second generation H1 receptor antagonist listed

all the other are first generation H1 receptor antagonist and have potent CNS effects that can causes drowsiness

Question 2

Amy is has to travel for her job and get motion sick on planes. What medication should she help treat her motion sickness.

A. Loratadine
B. Sumatriptan 
C.Chlorpheniramine 
D. Cyproheptadine 
E. Nizatidine 

RFA

Answer 2

ANS. C .Chlorpheniramine- is a first generation H1 antagonist the CNS effects can cause drowsiness but are also effective in treating motion sickness

A. Loradine- is second generation H1 antagonist so has little CNS effect so will be effective in allergy treatment but not motion sickness

B. Sumatriptan- is a 5Ht 1D/1B receptor agonist and is useful in the treatment of migraines

D. Cyproheptadine- is 5-HT2 receptor antagonist, it also blocks H1, and is used in allergic rhinitis, vasomotor rhinitis and serotonin syndrome

E. Nizatine- is a H2 receptor antagonist they inhibit gastric acid secretion

Question 3

A 35 y/o obese male presents for c/o GERD. You prescribe which H2 receptor antagonist?

A. Nizatidine
B. Cetirizine
C. Hydroxyzine
D. Cyclizine
E. Dimenhydrinate

SZ

Answer 3

Ans A. Nizatidine

Rest are H1 first and second generations