7. Pharmacodynamics II; No Images

Question 1

You are evaluating two different drugs used in the treatment of mycobacterium tuberculosis. You find that Drug B’s EC50 is lower than that of Drug A. This means that Drug B has more… (MG)

A. Efficacy
B. Potency
C. Toxicity
D. Binding affinity

Answer 1

B. Potency

Question 2

A 77 year old male presents to the clinic with rheumatoid arthritis pain that has gradually worsened over the past month. He has been taking vicodin for pain relief for the past 2 years for his condition. However, the same dose is not giving the same amount of relief. What term refers to this scenario? (MG)

A. Dependence
B. Refractoriness
C. Drug resistance
D. Desensitization
E. Tachyphylaxis

Answer 2

B. Refractoriness

Tolerance would also be correct if it was an option

D and E refer to a quicker (within a few minutes) decline of a drug’s effect and are synonymous with one another

Question 3

Which of the following is not an example of an inverse agonist?

A. Famotidine
B. Protamine
C. Losartan
D. Metaprolol
E. Risperidone

SZ

Answer 3

Ans. B Protamine is an example if a chemical antagonist.

Inverse agonist reverse constitutive activity, act like a competitive antagonist. These other examples are listed in the extra “essential” doc posted on Sakai.

Question 4

Which of the following pairs have a similar graphical representation? (more than one answer)

A. Ketamine and Aspirin
B. Aspirin and Omeprazole
C. Ketamine and Phenoxybenzamine
D. Epi and  Protamine
E. Aspirin and Protamine 

SZ

Answer 4

Ans. A, B, C all correct

Ketamine is a noncompetitive antagonist which has the same graph as irreversible competitive drugs (aspirin, omeprazole, and phenoxybenzamine)