20. GI Drugs

Question 1

Jim a 30 year old construction worker has been suffering from diarrhea he takes some Loperamide to treat his symptoms. What is the method of action of this drug?

A. Stimulates type 2 chloride channels
B. Active mu-opioid receptors
C. Decreasing fluid secretion in the enteric tract
D. Monoclonal antibody targeting integrins
E. Inhibits mu-opioid receptors

RFA

Answer 1

Ans. B .Actives mu0 opioid receptors- describes the action of Loperamide

A. Stimulates type 2 chloride channels- action of antidiarrheal drugs like Lubiprostone

C. Decreasing fluid secretion in the enteric tract- this is the action of antidiarrheal like Bismuth subsalicylate used for traveler’s diarrhea

D. Monoclonal antibody targeting integrins- describes Natalizumab which is a drug used in Crohn’s

E. Inhibits mu-opioid receptors - is the action of anti-constipation drugs like Alvimopan and Methylnaltrexone