30. Antimalarials

Question 1

Lisa is traveling to a part of Panama that is is endemic for Chloroquine sensitive uncomplicated malaria. What is the method of action of the drug she would be put on to prevent Malaria?

A. Prevents bile crystallization of hemoglobin breakdown heme to non-toxic hemozoin
B. Destruction of asexual blood forms of malarial pathogens
C. Inhibit Dihydrofolate reductase
D. Depresses O2 uptake and carbohydrate metabolism
E. Binds to iron breaking down, peroxide bridges leading to generation of free radicals that damage parasite proteins

RFA

Answer 1

ANS.

A Lisa is in a Chloroquine sensitive area so you are gonna give her Chloroquine and A. is how Chloroquine works so…..

B. MOA of Mefloquine- which is effective against chloroquine resistant strains of malaria

C. MOA of Pyrimethamine and Proguanil used in treatment of chloroquine resistant falciparum malaria.

D. This the MOA of Quinine and Quinidine- first line for severe falciparum

E. MOA of Artemisinin used in treatment of serve falciparum malaria

Question 2

A 18 year old women in South Sudan is in her 2nd trimester of pregnancy and gone into a coma. Blood work is done coming back positive for Plasmodium. malariae. Which of the listed medication would be the best to give for her condition?

A.Quinine 
B. Artemether 
C.  Mefloquine 
D.  Chloroquine 
E. Clindamycin

RFA

Answer 2

Ans. B. Artemether- while artesunate is first option it is not listed so artemether is best for severe malaria during 2nd & 3rd trimester

A. Quinidine- is for 1st trimester of severe malaria during prego

C. Mefloquine- is given to patients with uncomplicated malaria that are chloroquine resistant

D. Chloroquine- if it is chloroquine sensitive and uncomplicated malaria this is your go to always

E. Clindamycin- dont give to to prego people