29. White Blood Cell Disorder-3

Question 1

A 8 year old with down syndrome is brought to the doctor due to complaints of bone pain. Blood test are done showing cells positive for Tdt and CD20+. What is connected to the “good prognosis” of this condition?

A. t(14;18) 
B. t(9:22) 
C. t (8:14)
D.t (15;17) 
E. t(12;21)

RFA

Answer 1

Ans. t(12;21) E. The patient has ALL( Down Syndrome, Tdt positive cells)- good prognosis

A. t(14;18)- Follicular lymphoma

B. t(9;22) bad prognosis ALL

C. t(8;14)-Burkitt’s lymphoma

D. t(15;17)- AML

Question 2

A 32 year old man is doctor with complaints of fever and weight loss. Examination is done which is notable for a large non-painful rubbery enlargement of the right axillary node. Blood samples are taken. Histological examination yields Reed sternberg cells. What else is notable of this condition?

A. Severe Pruritus after warm showers
B. CD15+ amd CD30+ cells 
C.  Birbeck Granules 
D. CD5+ B cells 
E. Dacrocytes 

RFA

Answer 2

Ans. B CD15+ and CD30+ Cells- Classic HL= CD15, CD30 and CD45-, Variant= CD20, CD45, CD15- and CD30-

A. Severe Pruritus after showers- is Polycythemia Vera- while HL patients can have skin itching the after shower reaction is a hallmark of PCV

C. Birbeck Granules- are tennis racket shaped cells that are hallmarks of Langerhan Cells Histolycotes

D. CD5+ B Cells- could be CLL, Mantle Cell Lymphoma or Small Lymphocytic Lymphoma

E. Dacrocytes- or tear drop cells are cells related to PCV