28. Hypothalamic & Pituitary Hormones

Question 1

A 42 year old man present to his doctor with large hand and a flattened brow. What drug should he started on?

A. Cabergoline
B.  Mecasermin
C. Somatrem 
D. Urofollitropin
E. Atosiban

RFA

Answer 1

Ans. A Cabergoline- the man has acromegaly and this drug inhibits GH

B. Mecasermin- IGF1 analog would promote growth

C. Somatrem- stimulates growth

D. Urofollitropin- increasease release of FSH & LH

E. Atosiban- Oxytocin antagonist would be used in preterm labor

Question 2

A 32 year old man is taking a drug to treat his a carcinoid tumor. What AE is most likely with this drug?

A. Steatorrhea 
B. Otis Media
C. Gynecomastia 
D. Lupus like reaction 
E. Hirsutism 

RFA

Answer 2

Ans. A Steatorrhea- is a side effect of Octreotide the DOC for: acromegaly, gastrinomas, insulinomas and carcinoid syndrome, AE: Steatorrhea, constipation and gallstones and B12 deficiency

B. Otis Media-Somatropin used for GH def.

C .Gynecomastia- Goserelin used for Male and Female infertility increase LH and FSH

D. Lupus like reaction- PTU and methimazole used to treat hyperthyroidism

E. Hirsutism- side effect of excess androgen